Kinetic barriers and the role of topology in protein and RNA folding


  • Tobin R. Sosnick

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA
    • University of Chicago, 929 East 57th Street, GCIS W107E, Chicago, IL 60637, USA; fax: (773) 702-0439.
    Search for more papers by this author


This review compares the folding behavior of proteins and RNAs. Topics covered include the role of topology in the determination of folding rates, major folding events including collapse, properties of denatured states, pathway heterogeneity, and the influence of the mode of initiation on the folding pathway.