p53 Family members p63 and p73 are SAM domain-containing proteins

Authors

  • Christopher D. Thanos,

    1. UCLA-DOE Laboratory of Structural Biology and Molecular Medicine and Department of Chemistry and Biochemistry, University of California-Los Angeles Los Angeles California 90095
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  • James U. Bowie

    Corresponding author
    1. UCLA-DOE Laboratory of Structural Biology and Molecular Medicine and Department of Chemistry and Biochemistry, University of California-Los Angeles Los Angeles California 90095
    • UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, and Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095
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Abstract

Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that are involved in protein-protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effectors.

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