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In this paper we summarize an integrated, operational model of losses due to earthquake impacts on transportation and industrial capacity, and how these losses affect the metropolitan economy. The procedure advances the information provided by transportation and activity system analysis techniques in ways that help capture the most important ecomonic implications of earthquakes. Network costs and origin-destination requirements are modeled endogenously and consistently. Indirect and induced losses associated with direct impacts on transportation and industrial capacity are distributed across zones and ecomonic sectors. Preliminary results are summarized for a magnitude 7.1 earthquake on the Elysian Park blind thrust fault in Los Angeles.