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Associations of acanthosis nigricans with metabolic abnormalities in polycystic ovary syndrome women with normal body mass index

Authors

  • Zhe Dong,

    1. Center of Assisted Reproductive Technology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China
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    • The present address of the first author is different from that where the work was carried out.
  • Jia Huang,

    1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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  • Lili Huang,

    1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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  • Xiaoli Chen,

    1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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  • Qianqian Yin,

    1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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  • Dongzi Yang

    Corresponding author
    1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
    • Center of Assisted Reproductive Technology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China
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Correspondence: Dongzi Yang, M.D., Ph.D., Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang Road, Guangzhou, Guangdong 510120, China. Email: yangdz@mail.sysu.edu.cn

Abstract

Acanthosis nigricans (AN) usually correlates to insulin resistance (IR) or obesity in obese populations, but adequate studies on the significance of AN in people with normal body mass index (BMI) have not been performed and discussed. Three hundred and thirty-nine polycystic ovary syndrome (PCOS) patients with normal BMI (<23 kg/m2) were recruited. The anthropometric and biochemical parameters of these patients were measured. In these patients with normal BMI, 33 (9.7%) women had AN, and six (1.77%) women were diagnosed with metabolic syndrome. Most of the anthropometric and biochemical variables associated with metabolic status were more unfavorable in the AN-positive group compared with the AN-negative groups. The prevalence of central obesity, IR and reduced high-density lipoprotein cholesterol (HDL-C) level were also significantly higher in the AN-positive group (< 0.05). In multiple regression analysis, presence of AN was still significantly associated with IR (odds ratio [OR] = 2.952, 95% confidence intervals [CI] = 1.367–6.376] and reduced HDL-C level (OR = 2.668, 95% CI = 1.160–6.135) after adjustments for age and BMI. Sensitivity, specificity, and positive and negative predictive values for AN to detect IR were 18.6%, 92.6%, 39.4% and 81.4%, respectively. In conclusion, presence of AN correlated with IR and reduced HDL-C level in PCOS women with normal BMI. AN status had high specificity to detect IR, but lack of sensitivity.

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