Conflict of interest: None.
Solitary angiokeratoma on palms and soles: A clinicopathological analysis of 21 cases
Article first published online: 5 JUN 2013
© 2013 Japanese Dermatological Association
The Journal of Dermatology
Volume 40, Issue 8, pages 653–656, August 2013
How to Cite
Wang, L., Gao, T. and Wang, G. (2013), Solitary angiokeratoma on palms and soles: A clinicopathological analysis of 21 cases. The Journal of Dermatology, 40: 653–656. doi: 10.1111/1346-8138.12192
- Issue published online: 5 AUG 2013
- Article first published online: 5 JUN 2013
- Manuscript Accepted: 31 MAR 2013
- Manuscript Received: 6 FEB 2013
- Wilms tumor 1
Angiokeratoma includes a group of unrelated diseases characterized by hyperkeratosis and dilation of vessels in the superficial dermis. In this study, 21 cases of solitary lesions located on palms and soles and histopathologically diagnosed as angiokeratoma were analyzed retrospectively. All lesions presented as red to violet macules or plaques. Histopathologically, all of them showed hyperkeratosis and vascular dilation in the papillary to deep dermis. The elongated vessels were of different sizes and shape, lined by a single layer of endothelial cells. In 13 lesions, the endothelial cells protruded into the lumen, forming a hobnail appearance. Immunohistochemical study showed the endothelial cells were positive for CD31 and CD34, negative for D2-40, and focally positive for Wilms tumor 1 (WT-1) in most cases. Our cases represented a rare type of angiokeratoma located on the palms and soles, in which the focal positivity of WT-1 was different from previously reported vascular proliferations.