• 1
    Lacerda T.L., Cardoso P.G., Augusto de Almeida L., Camargo I.L., Afonso D.A., Trant C.C., Macedo G.C., Campos E., Cravero S.L., Salcedo S.P., Gorvel J.P., Oliveira S.C. (2010) Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice. Vaccine 28: 562734.
  • 2
    Ficht T.A. (2003) Intracellular survival of Brucella: defining the link with persistence. Vet Microbiol 92: 21323.
  • 3
    Elzer P.H., Hagius S.D., Davis D.S., DelVecchio V.G., Enright F.M. (2002) Characterization of the caprine model for ruminant brucellosis. Vet Microbiol 90: 42531.
  • 4
    Godfroid J., Cloeckaert A., Liautard J.P., Kohler S., Fretin D., Walravens K., Garin-Bastuji B., Letesson J.J. (2005) From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis. Vet Res 36: 31326.
  • 5
    Hamdy M.E., El-Gibaly S.M., Montasser A.M. (2002) Comparison between immune responses and resistance induced in BALB/c mice vaccinated with RB51 and Rev.1 vaccines and challenged with Brucella melitensis bv. 3. Vet Microbiol 88: 8594.
  • 6
    Elberg S.S., Faunce K. Jr., (1957) Immunization against Brucella infection. VI. Immunity conferred on goats by a nondependent mutant from a streptomycin independent mutant strain of Brucella melitensis. J Bacteriol 73: 2117.
  • 7
    Elberg S.S. (1996) Rev.1 Brucella melitensis vaccine. Part III: 1981–1995. Vet Bull 66: 1193200.
  • 8
    Research Group of Brucellosis (Harbin Veterinary Research Institute). (1991) Study on the Brucella melitensis strain M5-90 vaccine. Chinese J Control Endemic Dis 6: 658.
  • 9
    Cosivi O., Corbel M.J. (1998) WHO consultation on the development of new/improved brucellosis vaccines. Biologicals 26: 3613.
  • 10
    Moller T.T., Franch P., Hojrup D.R., Keene H.P., Bächinger R.G., Brennan R.G., Valentin-Hansen P. (2002) Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell 9: 2330.
  • 11
    Sieira R., Comerci D.J., Sánchez D.O., Ugalde R.A. (2000) A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence intracellular multiplication. J Bacteriol 182: 484955.
  • 12
    Vytvytska O., Moll I., Kaberdin V.R., von Gabain A., Bläsi U. (2000) Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. Genes Dev 14: 110918.
  • 13
    Caswell C.C., Gaines J.M., Roop R.M. (2012) The RNA chaperone Hfq independently coordinates expression of the VirB type IV secretion system and the LuxR-type regulator BabR in Brucella abortus 2308. J Bacteriol 194: 314.
  • 14
    Robertson G.T., Roop R.M. (1999) The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice. Mol Microbiol 34: 690700.
  • 15
    Roop R.M., Robertson G.T., Grippe V.K., Kovach M.E., LeVier K., Hagius S., Walker J.V., Booth N., Fulton T., Elzer P.H., Walker G.C., (2000) Virulence of Brucella melitensis hfq, katE and bacA mutants in pregnant goats. Proceedings of the 53rd Annual Brucellosis Research Conference, p. 89.
  • 16
    O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M. (1999) A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Plt type IV secretion systems is essential for intracellular survival of Brucella suis. Mol Microbiol 33: 121020.
  • 17
    Zygmunt M.S., Hagius S.D., Walker V.J., Elzer P.H. (2006) Identification of Brucella melitensis 16M genes required for bacterial survival in the caprine host. Microbes Infect 8: 284954.
  • 18
    Wang Y., Chen Z., Qiao F., Ying T., Yuan J., Zhong Z., Zhou L., Du X., Wang Z., Zhao J., Dong S., Jia L., Yuan X., Yang R., Sun Y., Huang L. (2009) Comparative proteomics analyses reveal the virB of B. melitensis affects expression of intracellular survival related proteins. PLoS ONE 4: e5368.
  • 19
    Adone R., Ciuchini F., Marianelli C., Tarantino M., Pistoia C., Marcon G., Petrucci P., Francia M., Riccardi G., Pasquali P. (2005) Protective properties of rifampin-resistant rough mutants of Brucella melitensis. Infect Immun 73: 4198312.
  • 20
    Liu W.X., Hu S., Qiao Z.J., Chen W.Y., Liu L.T., Wang F.K., Hua R.H., Bu Z.G., Li X.R. (2011) Expression, purification, and improved antigenic specificity of a truncated recombinant bp26 protein of Brucella melitensis M5-90: a potential antigen for differential serodiagnosis of brucellosis in sheep and goats. Biotechnol Appl Biochem 58: 3240.
  • 21
    Ashford D.A., di Pietra J., Lingappa J., Woods C., Noll H., Neville B., Weyant R., Bragg S.L., Spiegel R.A., Tappero J., Perkins B.A. (2004) Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51. Vaccine 22: 34359.
  • 22
    Berkelman R.L. (2003) Human illness associated with use of veterinary vaccines. Clin Infect Dis 37: 40714.
  • 23
    Schurig G.G., Sriranganathan N., Corbel M.J. (2002) Brucellosis vaccines: past, present and future. Vet Microbiol 90: 47996.
  • 24
    Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L., Brinkac L.M., Beanan M.J., Daugherty S.C., Deboy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. (2002) The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proc Natl Acad Sci USA 99: 1314853.
  • 25
    Moriyón I., Grilló M.J., Monreal D., González D., Marín C., López-Goñi I., Mainar-Jaime R.C., Moreno E., Blasco J.M. (2004) Rough vaccines in animal brucellosis: structural and genetic basis and present status. Vet Res 35: 138.
  • 26
    Golding B., Scott D.E., Scharf O., Huang L.Y., Zaitseva M., Lapham C., Eller N., Golding H. (2001) Immunity and protection against Brucella abortus. Microbes Infect 3: 438.
  • 27
    Sathiyaseelan J., Goenka R., Parent M., Benson R.M., Murphy E.A., Fernandes D.M., Foulkes A.S., Baldwin C.L. (2006) Treatment of Brucella susceptible mice with IL-12 increases primary and secondary immunity. Cell Immunol 243: 19.
  • 28
    Janeway C.A., Jr, Carding S., Jones B., Murray J., Portoles P., Rasmussen R., Rojo J., Saizawa K., West J., Bottomly K. (1988) CD4+ T cells: specificity and function. Immunol Rev 101: 3980.
  • 29
    Mosmann T.R., Sad S. (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17: 13846.
  • 30
    Raz E., Tighe H., Sato Y., Corr M., Dudler J.A., Roman M., Swain S.L., Spiegelberg H.L., Carson D.A. (1996) Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 93: 51415.
  • 31
    Wang Y., Bai Y., Qu Q., Xu J., Chen Y., Zhong Z., Qiu Y., Wang T., Du X., Wang Z., Yu S., Fu S., Yuan J., Zhen Q., Yu Y., Chen Z., Huang L. (2011) The 16M ΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. Vet Microbiol 151: 35462.