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Keywords:

  • human bocavirus;
  • interleukin-8;
  • respiratory syncytial virus;
  • tumor necrosis factor alpha

ABSTRACT

To investigate systemic cytokine responses in human bocavirus (HBoV)-associated lower respiratory tract infection, serum cytokine profiles were analyzed in HBoV positive-children (n = 14) using multiplex immunoassay. Concentrations of TNF-α, IL-2, IL-5 and IL-8 on admission were significantly different from those of respiratory syncytial virus-positive children (n = 28). This unique cytokine response might partly explain some characteristic clinical features of HBoV-associated respiratory infection.