These two authors contributed equally to this work.
Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in Chinese men
Article first published online: 30 MAR 2013
© 2013 The Authors Clinical and Experimental Pharmacology and Physiology © 2013 Wiley Publishing Asia Pty Ltd
Clinical and Experimental Pharmacology and Physiology
Volume 40, Issue 4, pages 282–288, April 2013
How to Cite
Dou, J., Ma, X., Fang, Q., Hao, Y., Yang, R., Wang, F., Zhu, J., Bao, Y. and Jia, W. (2013), Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in Chinese men. Clinical and Experimental Pharmacology and Physiology, 40: 282–288. doi: 10.1111/1440-1681.12063
- Issue published online: 30 MAR 2013
- Article first published online: 30 MAR 2013
- Accepted manuscript online: 31 JAN 2013 11:40AM EST
- Manuscript Accepted: 21 JAN 2013
- Manuscript Revised: 16 JAN 2013
- Manuscript Received: 17 JUL 2012
- insulin resistance;
- non-alcoholic fatty liver disease;
- The present study was designed to investigate the relationship between serum osteocalcin levels and non-alcoholic fatty liver disease (NAFLD) in Chinese men.
- In all, 1558 men (21–78 years old) were recruited to the study. Serum osteocalcin, glucose and lipid profiles were determined. Demographic and clinical characteristics were recorded. All participants underwent hepatic ultrasonographic examination.
- Serum osteocalcin levels were significantly lower in subjects with NAFLD than those without (P < 0.01). All study subjects were divided into four subgroups according to quartiles of serum osteocalcin levels. The frequency of NAFLD increased progressively with declining serum osteocalcin levels (Ptrend < 0.01). Serum osteocalcin levels were inversely correlated with NAFLD (P < 0.01). However, the significant association between serum osteocalcin levels and NAFLD disappeared in logistic regression analyses. Furthermore, multiple stepwise regression analysis showed that serum osteocalcin levels were independently associated with serum alanine aminotransferase levels in Chinese men (P < 0.01).
- The findings of the present study suggest that serum osteocalcin levels are not directly correlated with NAFLD.