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Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in Chinese men

Authors

  • Jianxin Dou,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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    • These two authors contributed equally to this work.
  • Xiaojing Ma,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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    • These two authors contributed equally to this work.
  • Qichen Fang,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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  • Yaping Hao,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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  • Rong Yang,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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  • Feifei Wang,

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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  • Jiaan Zhu,

    1. Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Institute of Ultrasound in Medicine, Shanghai, China
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  • Yuqian Bao,

    Corresponding author
    1. Shanghai Clinical Center for Diabetes, Shanghai, China
    2. Shanghai Diabetes Institute, Shanghai, China
    3. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
    • Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
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  • Weiping Jia

    1. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
    2. Shanghai Clinical Center for Diabetes, Shanghai, China
    3. Shanghai Diabetes Institute, Shanghai, China
    4. Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
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Correspondence: Professor Yuqian Bao, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China. Email: byq522@163.com

Summary

  1. The present study was designed to investigate the relationship between serum osteocalcin levels and non-alcoholic fatty liver disease (NAFLD) in Chinese men.
  2. In all, 1558 men (21–78 years old) were recruited to the study. Serum osteocalcin, glucose and lipid profiles were determined. Demographic and clinical characteristics were recorded. All participants underwent hepatic ultrasonographic examination.
  3. Serum osteocalcin levels were significantly lower in subjects with NAFLD than those without (< 0.01). All study subjects were divided into four subgroups according to quartiles of serum osteocalcin levels. The frequency of NAFLD increased progressively with declining serum osteocalcin levels (Ptrend < 0.01). Serum osteocalcin levels were inversely correlated with NAFLD (< 0.01). However, the significant association between serum osteocalcin levels and NAFLD disappeared in logistic regression analyses. Furthermore, multiple stepwise regression analysis showed that serum osteocalcin levels were independently associated with serum alanine aminotransferase levels in Chinese men (< 0.01).
  4. The findings of the present study suggest that serum osteocalcin levels are not directly correlated with NAFLD.

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