- This clinical review summarizes the evidence in relation to clinical outcomes from drug–drug and drug–disease interactions in older people.
- Exposure to drug–drug interactions is associated with increased risk of hospitalization-related outcomes in older people. Drug–disease interactions have been linked with adverse drug interactions and adverse drug events in studies of older people.
- Although the prevalence of drug–drug and drug–disease interactions is common in older people, there are very limited empirical data on important clinical outcomes from drug–drug and drug–disease interactions.
- Clinical implications of interactions between drugs and geriatric syndromes such as frailty, falls, cognitive impairment, immobility and urinary incontinence should also be considered in older people.