These authors contributed equally to this work.
Frontiers in Research Review: ISH Early Origins of Hypertension Workshop: Early Life Exposure and Development of a Healthy Heart
Regulation of fetal lung development in response to maternal overnutrition
Article first published online: 27 OCT 2013
© 2013 Wiley Publishing Asia Pty Ltd
Clinical and Experimental Pharmacology and Physiology
Volume 40, Issue 11, pages 803–816, November 2013
How to Cite
Lock, M., McGillick, E. V., Orgeig, S., McMillen, I. C. and Morrison, J. L. (2013), Regulation of fetal lung development in response to maternal overnutrition. Clinical and Experimental Pharmacology and Physiology, 40: 803–816. doi: 10.1111/1440-1681.12166
This paper has been peer reviewed.
- Issue published online: 27 OCT 2013
- Article first published online: 27 OCT 2013
- Accepted manuscript online: 10 SEP 2013 12:59AM EST
- Manuscript Accepted: 3 SEP 2013
- Manuscript Revised: 18 AUG 2013
- Manuscript Received: 23 JUN 2013
- With the worldwide obesity epidemic, the proportion of women entering pregnancy overweight or obese has increased significantly in recent years.
- Babies born to obese women are at an increased risk of respiratory complications at birth and in childhood.
- In addition to maternal diabetes, there are a number of metabolic changes that the fetus of an overnourished mother experiences in utero that may modulate lung development and represent the mechanisms underlying the increased risk of respiratory complications.
- Herein we highlight a series of factors associated with the intrauterine environment of an overnourished mother that may impact on fetal lung development and lead to an increased risk of complications at birth or in postnatal life.