Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers
Article first published online: 1 NOV 2012
© 2012 Society for Applied Microbiology and Blackwell Publishing Ltd
Volume 15, Issue 4, pages 1040–1049, April 2013
How to Cite
Geueke, B., Garg, N., Ghosh, S., Fleischmann, T., Holliger, C., Lal, R. and Kohler, H.-P. E. (2013), Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers. Environmental Microbiology, 15: 1040–1049. doi: 10.1111/1462-2920.12009
- Issue published online: 4 APR 2013
- Article first published online: 1 NOV 2012
- Accepted manuscript online: 9 OCT 2012 03:56AM EST
- Manuscript Accepted: 26 SEP 2012
- Manuscript Revised: 18 SEP 2012
- Manuscript Received: 16 JUL 2012
- Indo-Swiss Collaboration in Biotechnology from the Swiss Agency in Development and Cooporation (SDC), Switzerland
- Department of Biotechnology (DBT), India
Fig. S1. Chemical structures of the five main HCH isomers, HeCH and their metabolites. Note that only one possible enantiomer of chiral compounds is shown for simplicity. HCH – 1,2,3,4,5,6-hexachlorocyclohexane; HeCH – 1,1,2,3,4,5,6-heptachlorocyclohexane; B1, D1, E1 – 2,3,4,5,6-pentachlorocyclohexanol; He1 – 2,3,4,4,5,6-hexachlorocyclohexanol; B2, D2, E2 – 2,3,5,6-tetrachlorocyclohexane-1,4-diol, PCCH – 2,3,4,5,6-pentachlorocyclohexene; HCCH – 1,2,3,4,5,6-hexachlorocyclohexene; A3, D3, G3 – 3,4,5,6-tetrachloro-2-cyclohexenol; G3b – 2,4,5,6-tetrachloro-2-cyclohexeneol; A4, T4, D4, G4 – 3,5,6-trichloro-2-cyclohexene-1,4-diol; He4 – 2,3,5,6-tetrachloro-2-cyclohexene-1,4-diol.
Fig. S2. EI mass spectra of the metabolites E4, D4b and He4.
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