Oral cavity contains distinct niches with dynamic microbial communities

Authors

  • Xin Xu,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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    • Authors contributing equally as first authors.
  • Jinzhi He,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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    • Authors contributing equally as first authors.
  • Jing Xue,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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    • Authors contributing equally as first authors.
  • Yan Wang,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Kun Li,

    1. College of Computer Science, Sichuan University, Chengdu, China
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  • Keke Zhang,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Qiang Guo,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Xianghong Liu,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Yuan Zhou,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Lei Cheng,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Mingyun Li,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Yuqing Li,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Yan Li,

    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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  • Wenyuan Shi,

    1. UCLA School of Dentistry, Los Angeles, CA, USA
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  • Xuedong Zhou

    Corresponding author
    1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    2. Department of Endodontics and Operative Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    • For correspondence. E-mail zhouxd@scu.edu.cn; Tel. 86 028 85501841; Fax 86 028 85582167.

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Summary

Microbes colonize human oral surfaces within hours after delivery. During postnatal development, physiological changes, such as the eruption of primary teeth and replacement of the primary dentition with permanent dentition, greatly alter the microbial habitats, which, in return, may lead to community composition shifts at different phases in people's lives. By profiling saliva, supragingival and mucosal plaque samples from healthy volunteers at different ages and dentition stages, we observed that the oral cavity is a highly heterogeneous ecological system containing distinct niches with significantly different microbial communities. More importantly, the phylogenetic microbial structure varies with ageing. In addition, only a few taxa were present across the whole populations, indicating a core oral microbiome should be defined based on age and oral niches.

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