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Magnetoencephalography in pediatric neuroimaging

Authors

  • Ritva Paetau

    Corresponding author
    1. Department of Child Neurology, Hospital for Children and Adolescents, University of Helsinki; Brain Research Unit, Helsinki University of Technology; BioMag Laboratory; Helsinki University Central Hospital, Finland
      Address for correspondence: Hospital for Children and Adolescents, P.O. Box 280, FIN-00029 HUS, Finland; e-mail: ritva.paetau@hus.fi
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Address for correspondence: Hospital for Children and Adolescents, P.O. Box 280, FIN-00029 HUS, Finland; e-mail: ritva.paetau@hus.fi

Abstract

Neural currents give rise to electroencephalogram (EEG) and magnetoencephalogram (MEG). MEG has selective sensitivity to tangential currents (from fissural cortex), and less distorted signals compared with EEG. A major goal of MEG is to determine the location and timing of cortical generators for event-related responses, spontaneous brain oscillations or epileptiform activity. MEG provides a spatial accuracy of a few mm under optimal conditions, combined with an excellent submillisecond temporal resolution, which together enable spatiotemporal tracking of distributed neural activities, e.g. during cognitive tasks or epileptic discharges. While the present focus of pediatric MEG is on tailored epilepsy surgery, the complete noninvasiveness of MEG also provides unlimited possibilities to study the brain functions of healthy and developmentally deviant children.

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