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Table S1. Average annual change in theincidence density per 1,000 patient days of S. aureus, E. coli,S. pneumoniae, E. faecium or E. faecalis bacteraemias as reported to EARSS between 2002 and 2008. Only laboratories which consistently reported and provided denominator data for all years were included. Results are based on GLMs with Poisson distribution.

Table S2. Average annual change in the numberof S. aureus, E. coli, S. pneumoniae, E. faecium and E.faecalis bacteraemia isolates reported to EARSS between 2002 and 2008, overall and per region, expressed as absolute change and relative change above or below the average for all species combined. Only laboratories which consistently reported for all years were included. Results are based on GLMs with Poisson distribution.

Table S3. Average annual change in the numberof methicillin resistant (MRSA) and susceptible (MSSA) S.aureus bacteraemia isolates reported to EARSS between 2002 and 2008, overall and per region. Only laboratories which consistently reported for all years were included. Separate estimates are given for the period before and after the tipping point of the MRSA trend in 2005. Results are based on GLMs with Poisson distribution.

Table S4. Average annual change in the numberof E. coli bacteraemia isolates resistant to third generation cephalosporins (G3C), fluoroquinolones (FQ), aminoglycosides (AMINO) or aminopenicillins (AMIPN) reported to EARSS between 2002 and 2008, overall and per region. Only laboratories which consistently reported for all years were included. Results are based on GLMs with Poisson distribution.

Table S5. Frequency (fraction of total numberof bacteraemia isolates reported per region) of E. coli, S.aureus, S. pneumoniae, E. faecalis, E. faecium bacteraemia isolates reported to EARSS in 2008, displayed per region.

Table S6. Number of bacteraemia isolates(percentage resistant) and incidence density per 1,000 patient-daysof fluoroquinolone resistant E. coli (FLUO), methicillinresistant S. aureus (MRSA) and third generationcephalosporin resistant E. coli (G3CREC) bacteraemias reported to EARSS in 2008, displayed per region.

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