Emergence of Klebsiella pneumoniae co-producing NDM-type and OXA-181 carbapenemases

Authors

  • M. N. D. Balm,

    Corresponding author
    1. Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore
    • Corresponding author: M. N. D. Balm, Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore City 119074, Singapore

      E-mail: michelle.balm@gmail.com

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  • M.-V. La,

    1. National Public Health Laboratory, Singapore City, Singapore
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  • P. Krishnan,

    1. National Public Health Laboratory, Singapore City, Singapore
    2. Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore City, Singapore
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  • R. Jureen,

    1. Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore
    2. National Public Health Laboratory, Singapore City, Singapore
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  • R. T. P. Lin,

    1. Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore
    2. National Public Health Laboratory, Singapore City, Singapore
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  • J. W. P. Teo

    1. Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore
    2. National Public Health Laboratory, Singapore City, Singapore
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Abstract

The emergence of carbapenemase-producing Enterobacteriaceae is a rapidly evolving threat worldwide. Here, we report the molecular characterization of two Klebsiella pneumoniae isolates carrying both blaOXA-181 and blaNDM-1 or blaNDM-5 isolated from epidemiologically unrelated patients in Singapore. The blaOXA-181 genes were found existing in different genetic environments.

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