• 1
    Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 2011; 17: 17911798.
  • 2
    Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228236.
  • 3
    Chen LF, Anderson DJ, Paterson DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. Infect Drug Resist 2012; 5: 133141.
  • 4
    Canton R, Akova M, Carmeli Y et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012; 18: 413431.
  • 5
    Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 2012; 25: 682707.
  • 6
    Wei ZQ, Du XX, Yu YS, Shen P, Chen YG, Li LJ. Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Antimicrob Agents Chemother 2007; 51: 763765.
  • 7
    Cai JC, Zhou HW, Zhang R, Chen GX. Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing β-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob Agents Chemother 2008; 52: 20142018.
  • 8
    Shen P, Wei Z, Jiang Y et al. Novel genetic environment of the carbapenem-hydrolyzing β-lactamase KPC-2 among Enterobacteriaceae in China. Antimicrob Agents Chemother 2009; 53: 43334338.
  • 9
    Qi Y, Wei Z, Li L et al. Detection of a common plasmid carrying blakpc-2 in Enterobacteriaceae isolates from distinct cities in China. Microb Drug Resist 2010; 16: 297301.
  • 10
    Yang Q, Wang H, Sun H, Chen H, Xu Y, Chen M. Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. Antimicrob Agents Chemother 2010; 54: 573577.
  • 11
    Chen S, Hu F, Xu X et al. High prevalence of kpc-2-type carbapenemase coupled with ctx-m-type extended-spectrum β-lactamases in carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China. Antimicrob Agents Chemother 2011; 55: 24932494.
  • 12
    Qi Y, Wei Z, Ji S, Du X, Shen P, Yu Y. St11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. J Antimicrob Chemother 2011; 66: 307312.
  • 13
    Wang Y, Cao W, Zhu X et al. Characterization of a novel Klebsiella pneumoniae sequence type 476 carrying both blakpc-2 and blaimp-4. Eur J Clin Microbiol Infect Dis 2012; 31: 18671872.
  • 14
    Sheng JF, Li JJ, Tu S et al. Blakpc and Rmtb on a single plasmid in Enterobacter amnigenus and Klebsiella pneumoniae isolates from the same patient. Eur J Clin Microbiol Infect Dis 2012; 31: 15851591.
  • 15
    Zhang R, Wang XD, Cai JC et al. Outbreak of Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae with high qnr prevalence in a Chinese hospital. J Med Microbiol 2011; 60: 977982.
  • 16
    Toth A, Damjanova I, Puskas E et al. Emergence of a colistin-resistant KPC-2-producing Klebsiella pneumoniae ST258 clone in Hungary. Eur J Clin Microbiol Infect Dis 2010; 29: 765769.
  • 17
    Grundmann H, Livermore DM, Giske CG et al. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill 2010; 15: pii: 19711.
  • 18
    Kitchel B, Rasheed JK, Patel JB et al. Molecular epidemiology of kpc-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 2009; 53: 33653370.
  • 19
    Naas T, Cuzon G, Villegas MV, Lartigue MF, Quinn JP, Nordmann P. Genetic structures at the origin of acquisition of the β-lactamase blakpc gene. Antimicrob Agents Chemother 2008; 52: 12571263.
  • 20
    Naas T, Cuzon G, Truong HV, Nordmann P. Role of iskpn7 and deletions in blakpc gene expression. Antimicrob Agents Chemother 2012; 56: 47534759.
  • 21
    Li G, Wei Q, Wang Y, Du X, Zhao Y, Jiang X. Novel genetic environment of the plasmid-mediated kpc-3 gene detected in Escherichia coli and Citrobacter freundii isolates from China. Eur J Clin Microbiol Infect Dis 2011a; 30: 575580.
  • 22
    Zhang X, Lu X, Zong Z. Enterobacteriaceae producing the kpc-2 carbapenemase from hospital sewage. Diagn Microbiol Infect Dis 2012a; 73: 204206.
  • 23
    Li B, Sun JY, Liu QZ, Han LZ, Huang XH, Ni YX. First report of Klebsiella oxytoca strain coproducing KPC-2 and IMP-8 carbapenemases. Antimicrob Agents Chemother 2011b; 55: 29372941.
  • 24
    CLSI. Performance standards for antimicrobial susceptibility testing; twenty-second informational supplement (m100-s22). Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA. 2012; Vol.32 No.3.
  • 25
    Zhang Y, Yang J, Ye L et al. Characterization of clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates, 2007–2009, China. Microb Drug Resist 2012b; 18: 465470.
  • 26
    Ribot EM, Fair MA, Gautom R et al. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli o157:H7, Salmonella, and Shigella for pulsenet. Foodborne Pathog Dis 2006; 3: 5967.
  • 27
    Tenover FC, Arbeit RD, Goering RV et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33: 22332239.
  • 28
    Yang J, Chen Y, Jia X et al. Dissemination and characterization of NDM-1-producing Acinetobacter pittii in an intensive care unit in China. Clin Microbiol Infect 2012; 18: E506E513.
  • 29
    Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008; 29: 10991106.
  • 30
    Neuner EA, Yeh JY, Hall GS et al. Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infections. Diagn Microbiol Infect Dis 2011; 69: 357362.
  • 31
    Tumbarello M, Viale P, Viscoli C et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012; 55: 943950.
  • 32
    Voulgari E, Zarkotou O, Ranellou K et al. Outbreak of oxa-48 carbapenemase-producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother 2013; 68: 8488.
  • 33
    Giske CG, Froding I, Hasan CM et al. Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blandm-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 2012; 56: 27352738.
  • 34
    Chmelnitsky I, Shklyar M, Hermesh O, Navon-Venezia S, Edgar R, Carmeli Y. Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258. J Antimicrob Chemother 2013; 68: 7483.
  • 35
    Bedenic B, Mazzariol A, Plecko V et al. First report of KPC-producing Klebsiella pneumoniae in Croatia. J Chemother 2012; 24: 237239.
  • 36
    Richter SN, Frasson I, Franchin E et al. KPC-mediated resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 2011: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units. Gut Pathog 2012; 4: 7.
  • 37
    Potron A, Kalpoe J, Poirel L, Nordmann P. European dissemination of a single OXA-48-producing Klebsiella pneumoniae clone. Clin Microbiol Infect 2011; 17: E24E26.
  • 38
    Cuzon G, Naas T, Nordmann P. Functional characterization of tn4401, a tn3-based transposon involved in blakpc gene mobilization. Antimicrob Agents Chemother 2011; 55: 53705373.