ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients


  • These guidelines are endorsed by Società Italiana Malattie Infettive e Tropicali (SIMIT), Brazilian Association of Professionals in Infection Control and Hospital Epidemiology (ABIH), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC), Società Italiana Multidisciplinare per la Prevenzione delle Infezioni nelle Organizzazioni Sanitarie Italiana Malattie (SIMPIOS), Indian Association of Medical Microbiologists Delhi & NCR Chapter (IAMM DC and NCR), and Colombian Association of Hospital Epidemiology (ACEH).

Corresponding author: E. Tacconelli, Division of Infectious Diseases, Department of Internal Medicine I, Tübingen University Hospital, Otfried-Müller-Strabe 10, 72076 Tübingen, Germany



Healthcare-associated infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB) are a leading cause of morbidity and mortality worldwide. These evidence-based guidelines have been produced after a systematic review of published studies on infection prevention and control interventions aimed at reducing the transmission of MDR-GNB. The recommendations are stratified by type of infection prevention and control intervention and species of MDR-GNB and are presented in the form of ‘basic’ practices, recommended for all acute care facilities, and ‘additional special approaches’ to be considered when there is still clinical and/or epidemiological and/or molecular evidence of ongoing transmission, despite the application of the basic measures. The level of evidence for and strength of each recommendation, were defined according to the GRADE approach.