Antihypertensive and antithrombotic activities of a commercial fermented milk product made with Lactobacillus casei Shirota and Streptococcus thermophilus

Authors

  • Karina N Domínguez-González,

    1. Departamento de Biotecnología, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
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  • Alma Cruz-Guerrero,

    1. Departamento de Biotecnología, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
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  • Humberto González-Márquez,

    1. Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
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  • Lorena Gómez-Ruiz,

    1. Departamento de Biotecnología, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
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  • Mariano García-Garibay,

    1. Departamento de Biotecnología, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
    2. Departamento de Ciencias de la Alimentación, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Lerma, Lerma de Villada, Edo. de México, México
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  • Judith Jiménez-Guzmán,

    1. Departamento de Ciencias de la Alimentación, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Lerma, Lerma de Villada, Edo. de México, México
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  • Gabriela Rodríguez-Serrano

    Corresponding author
    1. Departamento de Biotecnología, División de Ciencias Biológicas y de la Salud, Unidad Iztapalapa, México, D.F., México
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Abstract

Peptides which inhibit the human angiotensin-converting enzyme (ACE) may be released during milk fermentation, and the micro-organisms or fermentation conditions influence the specific peptides produced. The aim of this study was to evaluate the ACE inhibitory and antithrombotic activities of a fermented milk product commercially available in Mexico. Viable cell numbers, protein hydrolysis and the pH remained constant during refrigerated storage. The IC50 of ACE inhibitory activity was 31.38 mg/mL. Eight peptide fractions exhibited ACE inhibitory activity and six showed antithrombotic activity. Two fractions showed both. This is the first time that both activities have been reported in a commercial probiotic product.

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