Image assessment of cervical dimensions after LLETZ: a prospective observational study

Authors

  • X Carcopino,

    Corresponding author
    1. Aix-Marseille Université (AMU), University of Medicine, Marseille, France
    • Department of Obstetrics and Gynaecology, Assistance Publique des Hôpitaux de Marseille (APHM), Marseille, France
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  • JA Maycock,

    1. Department of Gynaecology, Colposcopy Clinic, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
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  • J Mancini,

    1. Aix-Marseille Université (AMU), University of Medicine, Marseille, France
    2. Department of Public Health and Epidemiology, Assistance Publique des Hôpitaux de Marseille (APHM), Marseille, France
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  • M Jeffers,

    1. Department of Pathology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
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  • K Farrar,

    1. Department of Gynaecology, Colposcopy Clinic, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
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  • M Martin,

    1. Department of Gynaecology, Colposcopy Clinic, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
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  • S Khalid,

    1. Department of Gynaecology, Colposcopy Clinic, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
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  • W Prendiville

    1. Department of Gynaecology, Colposcopy Clinic, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    2. Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, The Coombe Women and Infants University Hospital, Dublin, Ireland
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Correspondence: Dr X Carcopino, Service de Gynécologie Obstétrique, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Chemin des Bourrely, 13915 Cedex 20, Marseille, France. Email xcarco@free.fr

Abstract

Objective

To assess the impact of large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia (CIN) on cervical morphology as assessed by three-dimensional ultrasound.

Design

Prospective observational study.

Setting

University Hospital in Dublin.

Population

Women with CIN who underwent an LLETZ procedure.

Methods

All 106 participants had a three-dimensional transvaginal ultrasound scan (3DTVS) performed immediately before and 6 months after LLETZ. The excised LLETZ specimen dimensions were also recorded. Blind analysis of the images was performed. The volume of the uterus and cervix was documented.

Main outcome measures

The relationship between the extirpated LLETZ dimensions and subsequent cervical and uterine biometry, as assessed by 3DTVS.

Results

LLETZ induced a statistically significant reduction in both the length (mean, –0.46 cm; < 0.001) and the volume (–6.12 cm3; < 0.001) of the uterus, and in the volume of the cervix (–1.60 cm3; < 0.001). The volume of the excised specimen had a significant impact on the reduction of the length of the uterus (β, –0.038; = 0.012), the volume of the uterus (β, –0.791; = 0.036) and the volume of the cervix (β, –0.121; = 0.046). The circumference of the excised specimen appeared to have a significant impact on the length (β, –0.016; 95% CI, –0.028 to –0.003; = 0.013) and volume (β, –0.413; 95% CI, –0.719 to –0.107; = 0.009) of the uterus 6 months after LLETZ.

Conclusions

The volume of tissue removed at LLETZ is related to the subsequent cervical volume, as well as the uterine length and volume, 6 months after the procedure.

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