• Open Access

Epidemiological investigation of a temporal increase in atonic postpartum haemorrhage: a population-based retrospective cohort study

Authors

  • A Mehrabadi,

    Corresponding author
    1. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    • Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada
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  • JA Hutcheon,

    1. Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada
    2. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    3. Perinatal Services BC, Vancouver, BC, Canada
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  • L Lee,

    1. Perinatal Services BC, Vancouver, BC, Canada
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  • MS Kramer,

    1. Departments of Pediatrics, Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
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  • RM Liston,

    1. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
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  • KS Joseph

    1. Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada
    2. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    3. Perinatal Services BC, Vancouver, BC, Canada
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Correspondence: A Mehrabadi, Room E418B, Shaughnessy Building, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1. Email azar@interchange.ubc.ca

Abstract

Objective

Increases in atonic postpartum haemorrhage (PPH) have been reported from several countries in recent years. We attempted to determine the potential cause of the increase in atonic and severe atonic PPH.

Design

Population-based retrospective cohort study.

Setting

British Columbia, Canada, 2001–2009.

Population

All women with live births or stillbirths.

Methods

Detailed clinical information was obtained for 371 193 women from the British Columbia Perinatal Data Registry. Outcomes of interest were atonic PPH and severe atonic PPH (atonic PPH with blood transfusion ≥1 unit; atonic PPH with blood transfusion ≥3 units or procedures to control bleeding), whereas determinants studied included maternal characteristics (e.g. age, parity, and body mass index) and obstetrics practice factors (e.g. labour induction, augmentation, and caesarean delivery). Year-specific unadjusted and adjusted odds ratios for the outcomes were compared using logistic regression.

Main outcome measures

Atonic PPH and severe atonic PPH.

Results

Atonic PPH increased from 4.8% in 2001 to 6.3% in 2009, atonic PPH with blood transfusion ≥1 unit increased from 16.6 in 2001 to 25.5 per 10 000 deliveries in 2009, and atonic PPH with blood transfusion ≥3 units or procedures to control bleeding increased from 11.9 to 17.6 per 10 000 deliveries. The crude 34% (95% CI 26–42%) increase in atonic PPH between 2001 and 2009 remained unchanged (42% increase, 95% CI 34–51%) after adjustment for determinants of PPH. Similarly, adjustment did not explain the increase in severe atonic PPH.

Conclusions

Changes in maternal characteristics and obstetric practice do not explain the recent increase in atonic and severe atonic PPH.

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