• 1
    Boskey ER, Telsch KM, Whaley KJ, Moench TR, Cone RA. Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infect Immun 1999;67:51705.
  • 2
    Zhou X, Bent SJ, Schneider MG, Davis CC, Islam MR, Forney LJ. Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods. Microbiology 2004;150:256573.
  • 3
    Coolen MJL, Post E, Davis CC, Forney LJ. Characterization of microbial communities found in the human vagina by analysis of terminal restriction fragment length polymorphisms of 16S rRNA genes. Appl Environ Microbiol 2005;71:872937.
  • 4
    Hyman RW, Fukushima M, Diamond L, Kumm J, Giudice LC, Davis RW. Microbes on the human vaginal epithelium. Proc Natl Acad Sci USA 2005;102:79527.
  • 5
    Zhou X, Brown CJ, Abdo Z, Davis CC, Hansmann MA, Joyce P, et al. Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. ISME J 2007;1:12133.
  • 6
    Zhou X, Hansmann MA, Davis CC, Suzuki H, Brown CJ, Schutte U, et al. The vaginal bacterial communities of Japanese women resemble those of women in other racial groups. FEMS Immunol Med Microbiol 2010;58:16981.
  • 7
    Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, Mculle SL, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011;108(Suppl 1):46807.
  • 8
    Gajer P, Brotman RM, Bai G, Sakamoto J, Schutte UM, Zhong X, et al. Temporal dynamics of the human vaginal microbiota. Sci Transl Med 2012;4:132ra52.
  • 9
    Peterson G, Allen CR, Holling CS. Ecological resilience, biodiversity, and scale. Ecosystems 1998;1:618.
  • 10
    Bartlett JG, Onderdonk AB, Drude E, Goldstein C, Anderka M, Alpert S, et al. Quantitative bacteriology of the vaginal flora. J Infect Dis 1977;136:2717.
  • 11
    Sautter RL, Brown WJ. Sequential vaginal cultures from normal young women. J Clin Microbiol 1980;11:47984.
  • 12
    Brown WJ. Variations in the vaginal bacterial flora: a preliminary report. Ann Intern Med 1982;96:9314.
  • 13
    Onderdonk AB, Zamarchi GR, Walsh JA, Mellor RD, Muñoz A, Kass EH. Methods for quantitative and qualitative evaluation of vaginal microflora during menstruation. Appl Environ Microbiol 1986;51:3339.
  • 14
    Larsen B, Galask RP. Vaginal microbial flora: composition and influences of host physiology. Ann Intern Med 1982;96:92630.
  • 15
    Johnson SR, Petzold CR, Galask RP. Qualitative and quantitative changes of the vaginal microbial flora during the menstrual cycle. Am J Reprod Immunol 1985;9:15.
  • 16
    Keane FE, Ison CA, Taylor-Robinson D. A longitudinal study of the vaginal flora over a menstrual cycle. Int J STD AIDS 1997;8:48994.
  • 17
    Schwebke JR, Morgan SC, Weiss HL. The use of sequential self-obtained vaginal smears for detecting changes in the vaginal flora. Sex Transm Dis 1997;24:2369.
  • 18
    Schwebke JR, Richey CM, Weiss HL. Correlation of behaviors with microbiological changes in vaginal flora. J Infect Dis 1999;180:16326.
  • 19
    Onderdonk AB, Zamarchi GR, Rodriguez ML, Hirsch ML, Muñoz A, Kass EH. Quantitative assessment of vaginal microflora during use of tampons of various compositions. Appl Environ Microbiol 1987;53:27748.
  • 20
    Eschenbach DA, Thwin SS, Patton DL, Hooton TM, Stapleton AE, Agnew K, et al. Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora. Clin Infect Dis 2000;30:9017.
  • 21
    Onderdonk AB, Zamarchi GR, Rodriguez ML, Hirsch ML, Muñoz A, Kass EH. Qualitative assessment of vaginal microflora during use of tampons of various compositions. Appl Environ Microbiol 1987;53:277984.
  • 22
    Wilks M, Tabaqchali S. Quantitative bacteriology of the vaginal flora during the menstrual cycle. J Med Microbiol 1987;24:2415.
  • 23
    Chow AW, Bartlett KH. Sequential assessment of vaginal microflora in healthy women randomly assigned to tampon or napkin use. Rev Infect Dis 1989;11(Suppl 1):S6873; discussion S73–4.
  • 24
    Shehin SE, Jones MB, Hochwalt AE, Sarbaugh FC, Nunn S. Clinical safety-in-use study of a new tampon design. Infect Dis Obstet Gynecol 2003;11:8999.
  • 25
    Chase DJ, Schenkel BP, Fahr A-M, Eigner U, Group TS. A prospective, randomized, double-blind study of vaginal microflora and epithelium in women using a tampon with an apertured film cover compared with those in women using a commercial tampon with a cover of nonwoven fleece. J Clin Microbiol 2007;45:121924.
  • 26
    Chase D, Schenkel B, Fahr A, Eigner U. Randomized, double-blind crossover study of vaginal microflora and epithelium in women using a tampon with a “winged” apertured film cover and a commercial tampon with a nonwoven fleece cover. J Clin Microbiol 2010;48:131722.
  • 27
    Vásquez A, Jakobsson T, Ahrné S, Forsum U, Molin G. Vaginal Lactobacillus flora of healthy Swedish women. J Clin Microbiol 2002;40:27469.
  • 28
    Falsen E, Pascual C, Sjödén B, Ohlén M, Collins MD. Phenotypic and phylogenetic characterization of a novel Lactobacillus species from human sources: description of Lactobacillus iners sp. nov. Int J Syst Bacteriol 1999;49:21721.
  • 29
    Li F, Hullar MAJ, Lampe JW. Optimization of terminal restriction fragment polymorphism (TRFLP) analysis of human gut microbiota. J Microbiol Methods 2007;68:30311.
  • 30
    Neefs JM, Van dePeerY, Hendriks L, De WachterR. Compilation of small ribosomal subunit RNA sequences. Nucleic Acids Res 1990;18(Suppl):2237317.
  • 31
    Legendre P, Gallagher E. Ecologically meaningful transformations for ordination of species data. Oecologia 2001;129:27180.
  • 32
    Ward JH Jr. Hierarchical grouping to optimize an objective function. J Am Stat Assoc 1963;58:23644.
  • 33
    Royston P. Remark AS. R94: A remark on Algorithm AS 181: The W test for normality. Journal of the Royal Statistical Society Series C (Applied Statistics) 1995;44:54751.
  • 34
    Oksanen J, Blanchet FG, Kindt R, Legendre P, Minchin PR, O'Hara RB, et al. vegan: Community Ecology Package. R package version 2.0-2. 2011. []. Accessed 16 May 2012.
  • 35
    Venables W, Ripley B. Statistics Complements to Modern Applied Statistics with S, 4th edn. Springer, New York. 2002;148.
  • 36
    Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J 2008;50:34663.
  • 37
    Ruckdeschel P, Kohl M, Stabla T, Camphausen F. S4 classes for distributions. R News: The Newsletter of the R Project 2006;6:26.
  • 38
    Neuwirth E. ColorBrewer: ColorBrewer palettes. R package version 1.0-5. 2011. []. Accessed 16 May 2012.
  • 39
    Langfelder P, Horvath S. moduleColor: Basic module functions. R package version 1.08-1. 2009. []. Accessed 16 May 2012.
  • 40
    Shannon CE. A Mathematical theory of communication. Mobile Comp Commun Rev 1963;5:547.
  • 41
    Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B 1995;57:289300.
  • 42
    Royston P. Remark AS R94: a remark on Algorithm AS 181: the W test for normality. Appl Stat 1995;44:54751.
  • 43
    Brotman RM, Ghanem KG, Klebanoff MA, Taha TE, Scharfstein DO, Zenilman JM. The effect of vaginal douching cessation on bacterial vaginosis: a pilot study. Am J Obstet Gynecol 2008;198:628.e1628.e7.