Stress and anxiety-depression levels following first-trimester miscarriage: a comparison between women who conceived naturally and women who conceived with assisted reproduction
Article first published online: 1 MAY 2013
© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 120, Issue 9, pages 1090–1097, August 2013
How to Cite
Stress and anxiety-depression levels following first-trimester miscarriage: a comparison between women who conceived naturally and women who conceived with assisted reproduction. BJOG 2013;120:1090–1097., , .
- Issue published online: 9 JUL 2013
- Article first published online: 1 MAY 2013
- Manuscript Accepted: 11 MAR 2013
- assisted reproduction;
To compare the psychological impact following early miscarriage between women who conceived naturally and women who conceived following assisted reproduction.
Prospective cohort study.
Assisted reproduction clinic and general gynaecological unit in a university-affiliated, tertiary referral hospital.
A cohort of 150 women (75 after natural conception; 75 after assisted reproduction).
Completed semi-structured interviews using two standard questionnaires [the 12-item General Health Questionnaire (GHQ-12) and the 22–item Revised Impact of Events Scale (IES-R)], at 1, 4, and 12 weeks after a diagnosis of first-trimester miscarriage.
Main outcome measures
The GHQ–12 and IES–R scores for the two groups of women.
The GHQ-12 and IES-R scores were significantly higher in the assisted reproduction group than the scores in the natural conception group, at 4 weeks and 12 weeks after miscarriage. Further breakdown of the scores revealed significantly higher hyperarousal symptoms at 4 and 12 weeks in the assisted reproduction group, indicating the traumatic effect of miscarriage to these women.
Following first-trimester miscarriage, subfertile women who conceived after assisted reproduction had higher stress and anxiety-depression levels, and experienced more traumatic impact from the event, than those after natural conception. A timely support and psychological intervention would be beneficial in the management of this group of women.