Association between gestational diabetes mellitus and subsequent overactive bladder among premenopausal female twins
Article first published online: 7 MAY 2013
© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 120, Issue 10, pages 1289–1295, September 2013
How to Cite
Association between gestational diabetes mellitus and subsequent overactive bladder among premenopausal female twins. BJOG 2013;120:1289–1295., , , , .
- Issue published online: 13 AUG 2013
- Article first published online: 7 MAY 2013
- Manuscript Accepted: 8 MAR 2013
- National Institute of Digestive Disorders and Kidney Diseases. Grant Number: U01 DK066134 to N.L.P.
- Swedish Research Council. Grant Number: K2010-21574-01–4 to D.A.
- OAB-LUTS Competitive Grants Program, Pfizer Inc.
- gestational diabetes;
- overactive bladder
To investigate the association between a history of gestational diabetes mellitus (GDM) and overactive bladder (OAB) in women of premenopausal age.
The Swedish Twin Register.
In 2005, a total of 14 094 female twins born between 1959 and 1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on GDM and OAB. The present study was designed as a cross-sectional analysis including all women in the cohort having given birth before 2005 (n = 7855).
A logistic regression model based on generalised estimating equations was used to derive odds ratios (ORs).
Main outcome measure
The association between a history of GDM and OAB was estimated using ORs with 95% confidence intervals (CIs).
The prevalence of OAB in women with a history of GDM was 19.1% compared with 10.7% in women without GDM. This corresponded to a two-fold increased odds of OAB in women with a history of gestational diabetes (OR 2.13, 95% CI 1.48–3.05). After adjusting the analysis for age, body mass index, parity, smoking, and diabetes mellitus, having had GDM was associated with doubled odds of OAB (OR 1.88, 95% CI 1.26–2.80).
A history of GDM was positively associated with OAB among women of premenopausal age. The association does not seem to be mediated by body mass index or type-I or type-II diabetes mellitus.