Association between gestational diabetes mellitus and subsequent overactive bladder among premenopausal female twins

Authors

  • G Tettamanti,

    Corresponding author
    1. Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    • Correspondence: Mr G Tettamanti, Department of Medical Epidemiology and Biostatistics, 171 77 Karolinska Institutet, Stockholm, Sweden. Email giorgio.tettamanti@ki.se

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  • AN Iliadou,

    1. Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
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  • NL Pedersen,

    1. Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
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  • R Bellocco,

    1. Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    2. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy
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  • D Altman

    1. Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    2. Department of Clinical Science, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
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Abstract

Objective

To investigate the association between a history of gestational diabetes mellitus (GDM) and overactive bladder (OAB) in women of premenopausal age.

Design

Population-based study.

Setting

The Swedish Twin Register.

Population

In 2005, a total of 14 094 female twins born between 1959 and 1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on GDM and OAB. The present study was designed as a cross-sectional analysis including all women in the cohort having given birth before 2005 (n = 7855).

Methods

A logistic regression model based on generalised estimating equations was used to derive odds ratios (ORs).

Main outcome measure

The association between a history of GDM and OAB was estimated using ORs with 95% confidence intervals (CIs).

Results

The prevalence of OAB in women with a history of GDM was 19.1% compared with 10.7% in women without GDM. This corresponded to a two-fold increased odds of OAB in women with a history of gestational diabetes (OR 2.13, 95% CI 1.48–3.05). After adjusting the analysis for age, body mass index, parity, smoking, and diabetes mellitus, having had GDM was associated with doubled odds of OAB (OR 1.88, 95% CI 1.26–2.80).

Conclusions

A history of GDM was positively associated with OAB among women of premenopausal age. The association does not seem to be mediated by body mass index or type-I or type-II diabetes mellitus.

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