Standardisation and quality control of ultrasound measurements taken in the INTERGROWTH-21st Project

Authors

  • I Sarris,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
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  • C Ioannou,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
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  • EO Ohuma,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
    2. Centre for Statistics in Medicine, University of Oxford, Oxford, UK
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  • DG Altman,

    1. Centre for Statistics in Medicine, University of Oxford, Oxford, UK
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  • L Hoch,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
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  • C Cosgrove,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
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  • S Fathima,

    1. Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
    2. Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK
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  • LJ Salomon,

    1. Université Paris V—René Descartes, Maternité Hôpital Necker-Enfants Malades, AP-HP, Paris, France
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  • AT Papageorghiou,

    Corresponding author
    • Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
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  • for the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st)


Correspondence: Dr AT Papageorghiou, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Email aris.papageorghiou@obs-gyn.ox.ac.uk

Abstract

Meticulous standardisation and ongoing monitoring of adherence to measurement protocols during data collection are essential to ensure consistency and to minimise systematic error in multicentre studies. Strict ultrasound fetal biometric measurement protocols are used in the INTERGROWTH-21st Project so that data of the highest quality from different centres can be compared and potentially pooled. A central Ultrasound Quality Unit (USQU) has been set up to oversee this process. After initial training and standardisation, the USQU monitors the performance of all ultrasonographers involved in the project by continuously assessing the quality of the images and the consistency of the measurements produced. Ultrasonographers are identified when they exceed preset maximum allowable differences. Corrective action is then taken in the form of retraining or simply advice regarding changes in practice. This paper describes the procedures used, which can form a model for research settings involving ultrasound measurements.

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