Second-trimester discordance and adverse perinatal outcome in twins: the STORK multiple pregnancy cohort
Article first published online: 6 DEC 2013
© 2013 Royal College of Obstetricians and Gynaecologists
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 121, Issue 4, pages 422–429, March 2014
How to Cite
Second-trimester discordance and adverse perinatal outcome in twins: the STROK multiple pregnancy cohort. BJOG 2014;121:422–429., , .
- Issue published online: 17 FEB 2014
- Article first published online: 6 DEC 2013
- Manuscript Accepted: 24 AUG 2013
- University of Chieti
- Pregnancy outcome;
- second trimester;
- twin pregnancies;
- weight discordance
The aim of this study was to determine the association between biometry discordance at the time of the anomaly scan and adverse perinatal outcomes in twin pregnancies.
Retrospective cohort study.
Nine hospitals in the Southwest Thames Region of London Obstetric Research Collaborative (STORK).
Population or sample
Population multicentre retrospective study of all twin pregnancies booked for antenatal care in nine hospitals over a period of 10 years. Methods Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to evaluate the association between abdominal circumference (AC) and estimated fetal weight (EFW) discordance, recorded between 20 and 22 weeks of gestation, and adverse pregnancy outcomes.
Main outcome measures
Stillbirth, neonatal mortality, preterm birth (PTB) at <34 weeks of gestation, and birthweight (BW) discordance ≥25%.
A total of 2399 twin pregnancies [457 monochorionic (MC) and 1942 dichorionic (DC)] were included in the study. The predictive accuracy of the EFW discordance was poor for fetal loss after 22 weeks of gestation (area under the curve, AUC 0.54, 95% CI 0.46–0.64), fetal loss beyond 28 weeks of gestation (AUC 0.42, 95% CI 0.31–0.52), perinatal loss (AUC 0.51, 95% CI 0.44–0.57), BW discordance (AUC 0.63, 95% CI 0.56–0.65), and PTB before 34 weeks of gestation (AUC 0.52, 95% CI 0.49–0.55). There was no significant difference in the prediction of these outcomes when using EFW discordance or AC discordance.
Once structural malformations, chromosomal abnormalities, and twin-to-twin transfusion syndrome have been excluded, second-trimester EFW and AC discordance have poor predictive value for adverse perinatal outcomes in twin pregnancy.