Intravenous ferrous sucrose versus placebo in addition to oral iron therapy for the treatment of severe postpartum anaemia: a randomised controlled trial
Article first published online: 15 JAN 2014
© 2014 Royal College of Obstetricians and Gynaecologists
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 121, Issue 6, pages 706–713, May 2014
How to Cite
Intravenous ferrous sucrose versus placebo in addition to oral iron therapy for the treatment of severe postpartum anaemia: a randomised controlled trial. BJOG 2014;121:706–713., , , , .
- Issue published online: 17 APR 2014
- Article first published online: 15 JAN 2014
- Manuscript Accepted: 6 SEP 2013
- Ferrous sulphate;
- intravenous iron sucrose;
- postpartum anaemia
The aim of the study was to evaluate the effectiveness of intravenous iron versus placebo added to standard oral iron therapy in the treatment of severe postpartum anaemia.
A randomised, double-blind, parallel-group, placebo-controlled clinical trial was performed in a single centre.
Hospital Clinic of Barcelona, Barcelona, Spain.
A cohort of 72 women with severe postpartum anaemia (6.0–8.0 g/dl) treated with oral ferrous sulphate (two tablets of 525 mg).
Women were randomised to receive either intravenous ferrous sucrose (200 mg/24 hours for two consecutive days) or intravenous placebo, in addition to standard iron therapy. Clinical and laboratory data were obtained at 1, 2, and 6 weeks.
Main outcome measures
Haemoglobin and haematocrit at 1, 2, and 6 weeks. Other haematological and clinical parameters, psychological status, and adverse side effects were also evaluated.
Haemoglobin and haematocrit values were comparable in women receiving intravenous iron or placebo in addition to oral iron therapy at any of the time points. At 6 weeks, haemoglobin level (mean ± SD) was 12.2 ± 1.0 versus 12.2 ± 0.9 g/dl, with a mean difference of −0.03 (95% CI −0.6 to 0.6), in the placebo and in the intravenous iron groups, respectively. No differences were found between clinical symptoms of anaemia, psychological status, and adverse side effects between groups.
Intravenous iron added to oral iron therapy did not show significant benefits over placebo, neither in haemoglobin rise nor in symptoms or adverse side effects.