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Data S1. Recipe of trace elements SL10 and SL12.

Data S2. Dissolved inorganic carbon (DIC) and pH from dialysis bags.

Data S3. Genome analysis.

Table S1. Physical parameters of the Lake Cadagno of the 12 September 2007.

Fig. S1. Specific FISH counting of GSB (white) and PSB (black) compared to the total prokaryotic cells counted by DAPI (grey) at different depths of Lake Cadagno during the day of the 14CO2 assimilation analysis from the cultures pre-incubated in dialysis bags (in situ, September 12, 2007).

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