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Keywords:

  • bacteriophage;
  • endolysin;
  • CHAP domain;
  • SH3b cell wall–binding domain;
  • Staphylococcus aureus

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall–binding domain is a potent agent against Staphylococcus aureus in four functional assays.