Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme

Authors


Correspondence: David M. Donovan, ABBL, BARC, Agricultural Research Service, US Department of Agriculture, 10300 Baltimore Avenue, Building 230, BARC-EAST, Beltsville, MD 20705, USA. Tel.: 301 504 9150; fax: 301 504 8571;

e-mail: david.donovan@ars.usda.gov

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall–binding domain is a potent agent against Staphylococcus aureus in four functional assays.

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