Pre-sporulation stages of Streptomyces differentiation: state-of-the-art and future perspectives

Authors

  • Paula Yagüe,

    1. Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
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  • Maria T. López-García,

    1. Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
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  • Beatriz Rioseras,

    1. Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
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  • Jesús Sánchez,

    1. Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
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  • Ángel Manteca

    Corresponding author
    • Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
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Correspondence: Ángel Manteca, Departamento de Biología Funcional and IUBA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain. Tel.: + 34985103555; fax: +34 985 103534; e-mail: mantecaangel@uniovi.es

Abstract

Streptomycetes comprise very important industrial bacteria, producing two-thirds of all clinically relevant secondary metabolites. They are mycelial microorganisms with complex developmental cycles that include programmed cell death (PCD) and sporulation. Industrial fermentations are usually performed in liquid cultures (large bioreactors), conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. In this work, we review the current knowledge on Streptomyces pre-sporulation stages of Streptomyces differentiation.

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