Draft genome sequences of two super-extensively drug-resistant isolates of Mycobacterium tuberculosis from China


Correspondence: Joy Fleming, Key Laboratory of Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Tel.: +86 1064888464; fax: +86 1064871293; e-mail: joyfleming@moon.ibp.ac.cn


Shihua Wang, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China. Tel./fax: +86 59187984471; e-mail: wshyyl@sina.com


The prevalence of drug-resistance in Mycobacterium tuberculosis is already having a negative impact on the control of tuberculosis. We report the draft genome sequences of two super-extensively drug-resistant M. tuberculosis isolates from China, FJ05194 (lineage 2) and GuangZ0019 (lineage 4), and compare them with the H37Rv reference strain to identify possible sources of genetic variation associated with their extensive drug resistance. Our results suggest that their extensive drug resistance probably results from the stepwise accumulation of resistances to individual drugs.