Leptospiral extracellular matrix adhesins as mediators of pathogen–host interactions

Authors

  • Monica L. Vieira,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
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  • Luis G. Fernandes,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Renan F. Domingos,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Rosane Oliveira,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Gabriela H. Siqueira,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Natalie M. Souza,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Aline R.F. Teixeira,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
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  • Marina V. Atzingen,

    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
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  • Ana L.T.O. Nascimento

    Corresponding author
    1. Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil
    2. Programa Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, SP, Brazil
    • Correspondence: Ana L.T.O. Nascimento, Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900 São Paulo, SP, Brazil. Tel.: 5511 2627 9829; fax: 5511 3726 9233; e-mail: ana.nascimento@butantan.gov.br

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Abstract

Leptospirosis is been considered an important infectious disease that affects humans and animals worldwide. This review summarizes our current knowledge of bacterial attachment to extracellular matrix (ECM) components and discusses the possible role of these interactions for leptospiral pathogenesis. Leptospiral proteins show different binding specificity for ECM molecules: some are exclusive laminin-binding proteins (Lsa24/LfhA/LenA, Lsa27), while others have broader spectrum binding profiles (LigB, Lsa21, LipL53). These proteins may play a primary role in the colonization of host tissues. Moreover, there are multifunctional proteins that exhibit binding activities toward a number of target proteins including plasminogen/plasmin and regulators of the complement system, and as such, might also act in bacterial dissemination and immune evasion processes. Many ECM-interacting proteins are recognized by human leptospirosis serum samples indicating their expression during infection. This compilation of data should enhance our understanding of the molecular mechanisms of leptospiral pathogenesis.

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