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  • Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C & Salas JA (2000) Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus. Antimicrob Agents Chemother 44: 12661275.
  • Alper H, Fischer C, Nevoigt E & Stephanopoulos G (2005) Tuning genetic control through promoter engineering. P Natl Acad Sci USA 102: 1267812683.
  • Anand S & Mohanty D (2012) Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study. BMC Struct Biol 12: 21.
  • Blin K, Medema MH, Kazempour D, Fischbach MA, Breitling R, Takano E & Weber T (2013) antiSMASH 2.0-a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res 41: W204W212.
  • Bonnett SA, Rath CM, Shareef AR, Joels JR, Chemler JA, Hakansson K, Reynolds K & Sherman DH (2011) Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chem Biol 18: 10751081.
  • Breaker RR (2008) Gene regulation by riboswitches. FASEB J 22: 1.
  • Caffrey P (2003) Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases. ChemBioChem 4: 654657.
  • Campbell CD & Vederas JC (2010) Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers 93: 755763.
  • Chan YA, Boyne MT, Podevels AM, Klimowicz AK, Handelsman J, Kelleher NL & Thomas MG (2006) Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. P Natl Acad Sci USA 103: 1434914354.
  • Chen XH, Vater J, Piel J et al. (2006) Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol 188: 40244036.
  • Chen AY, Cane DE & Khosla C (2007) Structure-based dissociation of a type I polyketide synthase module. Chem Biol 14: 784792.
  • Donadio S, Staver MJ, McAlpine JB, Swanson SJ & Katz L (1991) Modular organization of genes required for complex polyketide biosynthesis. Science 252: 675679.
  • Donadio S, McAlpine JB, Sheldon PJ, Jackson M & Katz L (1993) An erythromycin analog produced by reprogramming of polyketide synthesis. P Natl Acad Sci USA 90: 71197123.
  • Donadio S, Sosio M, Stegmann E, Weber T & Wohlleben W (2005) Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis. Mol Genet Genomics 274: 4050.
  • Doumith M, Legrand R, Lang C, Salas JA & Raynal MC (1999) Interspecies complementation in Saccharopolyspora erythraea: elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives. Mol Microbiol 34: 10391048.
  • Eustaquio AS, McGlinchey RP, Liu Y et al. (2009) Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. P Natl Acad Sci USA 106: 1229512300.
  • Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton JU & Leadlay PF (2000) A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Mol Microbiol 36: 391401.
  • Georg J & Hess WR (2011) cis-Antisense RNA, Another Level of Gene Regulation in Bacteria. Microbiol Mol Biol Rev 75: 286300.
  • Goranovic D, Blazic M, Magdevska V et al. (2012) FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis. BMC Microbiol 12: 238.
  • Guell M, Yus E, Lluch-Senar M & Serrano L (2011) Bacterial transcriptomics: what is beyond the RNA horiz-ome? Nat Rev Microbiol 9: 658669.
  • Han AR, Park JW, Lee MK, Ban YH, Yoo YJ, Kim EJ, Kim E, Kim BG, Sohng JK & Yoon YJ (2011) Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl Environ Microbiol 77: 49124923.
  • Hertweck C (2009) The biosynthetic logic of polyketide diversity. Angew Chem Int Ed Engl 48: 46884716.
  • Hurteloup P & Ganzina F (1986) Clinical studies with new anthracyclines epirubicin, idarubicin, esorubicin. Drugs Exp Clin Res 12: 233246.
  • Ishihama A (2010) Prokaryotic genome regulation: multifactor promoters, multitarget regulators and hierarchic networks. FEMS Microbiol Rev 34: 628645.
  • Jacobsen JR, Hutchinson CR, Cane DE & Khosla C (1997) Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 277: 367369.
  • Kantola J, Kunnari T, Mantsala P & Ylihonko K (2003) Expanding the scope of aromatic polyketides by combinatorial biosynthesis. Comb Chem High Throughput Screening 6: 501512.
  • Kao CM, Luo GL, Katz L, Cane DE & Khosla C (1994) Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase. J Am Chem Soc 116: 1161211613.
  • Kao CM, Luo GL, Katz L, Cane DE & Khosla C (1995) Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase. J Am Chem Soc 117: 91059106.
  • Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE & Khosla C (2012) Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. P Natl Acad Sci USA 109: 41104115.
  • Kennedy J (2008) Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat Prod Rep 25: 2534.
  • Knight TF (2003) Idempotent vector design for standard assembly of BioBricks. MIT Synthetic Biology Working Group Technical Reports.
  • Koskinen AMP & Karisalmi K (2005) Polyketide stereotetrads in natural products. Chem Soc Rev 34: 677690.
  • Lai JR, Koglin A & Walsh CT (2006) Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis. Biochemistry 45: 1486914879.
  • Lesnik U, Gormand A, Magdevska V, Fujs S, Raspor P, Hunter I & Petkovic H (2009) Regulatory elements in tetracycline-encoding gene clusters: the otcG gene positively regulates the production of oxytetracycline in Streptomyces rimosus. Food Technol Biotechnol 47: 323330.
  • Liu Y, Hazzard C, Eustaquio AS, Reynolds KA & Moore BS (2009) Biosynthesis of salinosporamides from alpha, beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. J Am Chem Soc 131: 1037610377.
  • Lockless SW & Muir TW (2009) Traceless protein splicing utilizing evolved split inteins. P Natl Acad Sci USA 106: 1099911004.
  • Long PF, Wilkinson CJ, Bisang CP et al. (2002) Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol 43: 12151225.
  • Ma SM & Tang Y (2007) Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB. FEBS J 274: 28542864.
  • Masschelein J, Mattheus W, Gao LJ et al. (2013) A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics. PLoS One 8: 1.
  • McDaniel R, Kao CM, Fu H, Hevezi P, Gustafsson C, Betlach M, Ashley G, Cane DE & Khosla C (1997) Gain-of-function mutagenesis of a modular polyketide synthase. J Am Chem Soc 119: 43094310.
  • McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M & Ashley G (1999) Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products. P Natl Acad Sci USA 96: 18461851.
  • Medema MH, Alam MT, Breitling R & Takano E (2011a) The future of industrial antibiotic production: from random mutagenesis to synthetic biology. Bioeng Bugs 2: 230233.
  • Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E & Breitling R (2011b) antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 39: W339W346.
  • Meier JL & Burkart MD (2009) The chemical biology of modular biosynthetic enzymes. Chem Soc Rev 38: 20122045.
  • Minotti G, Menna P, Salvatorelli E, Cairo G & Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185229.
  • Mironov VA, Sergienko OV, Nastasyak IN & Danilenko VN (2004) Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora erythraea. Appl Biochem Microbiol 40: 531541.
  • Mo S, Kim DH, Lee JH et al. (2011) Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc 133: 976985.
  • Moore BS & Hertweck C (2002) Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep 19: 7099.
  • Olano C, Mendez C & Salas JA (2010) Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep 27: 571616.
  • Oliynyk M, Brown MJB, Cortes J, Staunton J & Leadlay PF (1996) A hybrid modular polyketide synthase obtained by domain swapping. Chem Biol 3: 833839.
  • Park SR, Yoo YJ, Ban YH & Yoon YJ (2010) Biosynthesis of rapamycin and its regulation: past achievements and recent progress. J Antibiot 63: 434441.
  • Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE & Khosla C (2001) Biosynthesis of complex polyketides in a metabolically engineered strain of E-coli. Science 291: 17901792.
  • Piel J (2010) Biosynthesis of polyketides by trans-AT polyketide synthases. Nat Prod Rep 27: 9961047.
  • Pohl NL, Hans M, Lee HY, Kim YS, Cane DE & Khosla C (2001) Remarkably broad substrate tolerance of Malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. J Am Chem Soc 123: 58225823.
  • Ramos A, Lombo F, Brana AF, Rohr J, Mendez C & Salas JA (2008) Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology 154: 781788.
  • Ranganathan A, Timoney M, Bycroft M et al. (1999) Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues. Chem Biol 6: 731741.
  • Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR & McDaniel R (2003) A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. Biochemistry 42: 7279.
  • Rix U, Fischer C, Remsing LL & Rohr J (2002) Modification of post-PKS tailoring steps through combinatorial biosynthesis. Nat Prod Rep 19: 542580.
  • Rodriguez L, Oelkers C, Aguirrezabalaga I, Brana AF, Rohr J, Mendez C & Salas JA (2000) Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways. J Mol Microbiol Biotechnol 2: 271276.
  • Rowe CJ, Bohm IU, Thomas IP et al. (2001) Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chem Biol 8: 475485.
  • Shis DL & Bennett MR (2013) Library of synthetic transcriptional AND gates built with split T7 RNA polymerase mutants. P Natl Acad Sci USA 110: 50285033.
  • Sundermann U, Bravo-Rodriguez K, Klopries S, Kushnir S, Gomez H, Sanchez-Garcia E & Schulz F (2013) Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. ACS Chem Biol 8: 443450.
  • Tang L & McDaniel R (2001) Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity. Chem Biol 8: 547555.
  • Temme K, Zhao DH & Voigt CA (2012) Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca. P Natl Acad Sci USA 109: 70857090.
  • Thattai M, Burak Y & Shraiman BI (2007) The origins of specificity in polyketide synthase protein interactions. PLoS Comput Biol 3: 18271835.
  • Vagstad AL, Newman AG, Storm PA, Belecki K, Crawford JM & Townsend CA (2013) Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. Angew Chem Int Ed Engl 52: 17181721.
  • Vasanthakumar A, Kattusamy K & Prasad R (2013) Regulation of daunorubicin biosynthesis in Streptomyces peucetius – feed forward and feedback transcriptional control. J Basic Microbiol 53: 636644.
  • Walsh CT & Fischbach MA (2010) Natural products version 2.0: connecting genes to molecules. J Am Chem Soc 132: 24692493.
  • Wang HH & Church GM (2011) Multiplexed genome engineering and genotyping methods: applications for synthetic biology and metabolic engineering. Synthetic Biology, Pt B: Computer Aided Design and DNA Assembly, Vol. 498 (Voigt C, ed.), pp. 409426. Elsevier Academic Press Inc, San Diego, CA.
  • Wang JB, Pan HX & Tang GL (2011) Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett 21: 33203323.
  • Weber T, Welzel K, Pelzer S, Vente A & Wohlleben W (2003) Exploiting the genetic potential of polyketide producing streptomycetes. J Biotechnol 106: 221232.
  • Weissman KJ & Leadlay PF (2005) Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 3: 925936.
  • Weymouth-Wilson AC (1997) The role of carbohydrates in biologically active natural products. Nat Prod Rep 14: 99110.
  • Williams GJ (2013) Engineering polyketide synthases and nonribosomal peptide synthetases. Curr Opin Struct Biol 23: 603612.
  • Wilson MC, Nam SJ, Gulder TAM, Kauffman CA, Jensen PR, Fenical W & Moore BS (2011) Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc 133: 19711977.
  • Wohlert SE, Blanco G, Lombó F et al. (1998) Novel hybrid tetracenomycins through combinatorial biosynthesis using a glycosyltransferase encoded by the elm genes in cosmid 16F4 and which shows a broad sugar substrate specificity. J Am Chem Soc 120: 1059610601.
  • Wu K, Chung L, Revill WP, Katz L & Reeves CD (2000) The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251: 8190.
  • Xu YQ, Zhou T, Zhang SW, Xuan LJ, Zhan JX & Molnar I (2013) Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis. J Am Chem Soc 135: 1078310791.
  • Yeh HH, Chang SL, Chiang YM, Bruno KS, Oakley BR, Wu TK & Wang CC (2013) Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping. Org Lett 15: 756759.
  • Yoon YJ, Beck BJ, Kim BS, Kang H-Y, Reynolds KA & Sherman DH (2002) Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem Biol 9: 203214.
  • Yu DY, Xu FC, Zeng J & Zhan JX (2012) Type III polyketide synthases in natural product biosynthesis. LUBMB Life 64: 285295.
  • Yuzawa S, Kapur S, Cane DE & Khosla C (2012) Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry 51: 37083710.