Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro
Article first published online: 28 APR 2014
© 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved
FEMS Microbiology Letters
Volume 355, Issue 1, pages 43–50, June 2014
How to Cite
Fan, L., Wang, Q., de la Fuente-Núñez, C., Sun, F.-J., Xia, J.-G., Xia, P.-Y. and Hancock, R. E.W. (2014), Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro. FEMS Microbiology Letters, 355: 43–50. doi: 10.1111/1574-6968.12441
- Issue published online: 9 JUN 2014
- Article first published online: 28 APR 2014
- Accepted manuscript online: 9 APR 2014 07:05AM EST
- Manuscript Accepted: 5 APR 2014
- Manuscript Revised: 24 MAR 2014
- Manuscript Received: 13 MAR 2014
- Natural Science Foundation of China. Grant Number: 81102481
- Natural Science Foundation Project of CQ CSTC. Grant Number: 2010BB5425
- Canada Research Chair in Health and Genomics
- Fundación ‘la Caixa’ and Fundación Canadá (Spain)
- Canadian Institutes of Health Research Postdoctoral Fellowship
- Killam Postdoctoral Research Fellowship
Fig. S1. LDH release in HBEs by different concentrations of AZM (0, 2, 4, 8, 16 μg mL−1)-treated PAO1, compared with LDH levels from uninfected HBE cells. *, using Student's t-test, P < 0.05.
Fig. S2. IL-8 expression in HBEs infected for 2 h with PAO1. *, compared with untreated PAO1, using Student's t-test, P < 0.05.
Fig. S3. IL-8 production in HBEs infected for 8 h with PAO1, which was pretreated with antimicrobials at concentrations of 1/4 MIC. *, using Student's t-test, P < 0.05.
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