Role of environmental survival in transmission of Campylobacter jejuni
Article first published online: 19 JUN 2014
© 2014 The Authors. FEMS Microbiology Letters published by John Wiley & Sons Ltd on behalf of Federation of European Microbiological Societies.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
FEMS Microbiology Letters
Volume 356, Issue 1, pages 8–19, July 2014
How to Cite
Bronowski, C., James, C. E. and Winstanley, C. (2014), Role of environmental survival in transmission of Campylobacter jejuni. FEMS Microbiology Letters, 356: 8–19. doi: 10.1111/1574-6968.12488
- Issue published online: 7 JUL 2014
- Article first published online: 19 JUN 2014
- Accepted manuscript online: 28 MAY 2014 10:05AM EST
- Manuscript Accepted: 24 MAY 2014
- Manuscript Revised: 20 MAY 2014
- Manuscript Received: 4 APR 2014
- Medical Research Council
- Natural Environment Research Council
- Economic and Social Research Council
- Biotechnology and Biosciences Research Council and Food Standards Agency
- Environmental & Social Ecology of Human Infectious Diseases Initiative. Grant Number: G1100799/1
- Campylobacter ;
Campylobacter species are the most common cause of bacterial gastroenteritis, with C. jejuni responsible for the majority of these cases. Although it is clear that livestock, and particularly poultry, are the most common source, it is likely that the natural environment (soil and water) plays a key role in transmission, either directly to humans or indirectly via farm animals. It has been shown using multilocus sequence typing that some clonal complexes (such as ST-45) are more frequently isolated from environmental sources such as water, suggesting that strains vary in their ability to survive in the environment. Although C. jejuni are fastidious microaerophiles generally unable to grow in atmospheric levels of oxygen, C. jejuni can adapt to survival in the environment, exhibiting aerotolerance and starvation survival. Biofilm formation, the viable but nonculturable state, and interactions with other microorganisms can all contribute to survival outside the host. By exploiting high-throughput technologies such as genome sequencing and RNA Seq, we are well placed to decipher the mechanisms underlying the variations in survival between strains in environments such as soil and water and to better understand the role of environmental persistence in the transmission of C. jejuni directly or indirectly to humans.