Yeast: a simple model system to study complex phenomena of aneuploidy

Authors

  • Wahid Mulla,

    Corresponding author
    1. Stowers Institute for Medical Research, Kansas City, MO, USA
    2. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
    • Correspondence: Wahid Mulla, Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. Tel.: +1 816-926-4103; fax: +1 816-926-4688;

      e-mail: wmu@stowers.org

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  • Jin Zhu,

    1. Stowers Institute for Medical Research, Kansas City, MO, USA
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  • Rong Li

    1. Stowers Institute for Medical Research, Kansas City, MO, USA
    2. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
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Abstract

Aneuploidy, the state of having a chromosome number different from a multiple of the haploid number, has been associated with diseases and developmental disorders. The role of aneuploidy in human disease pathology, especially in cancer, has been a subject of much attention and debate over the last century due to the intrinsic complexity of the phenomena and experimental challenges. Over the last decade, yeast has been an invaluable model for driving discoveries about the genetic and molecular aspects of aneuploidy. The understanding of aneuploidy has been significantly improved owing to the methods for selectively generating aneuploid yeast strains without causing other genetic changes, techniques for detecting aneuploidy, and cutting-edge genetics and ‘omics’ approaches. In this review, we discuss the contribution of studies in yeast to current knowledge about aneuploidy. Special emphasis is placed on experimental features that make yeast a simpler and efficient model to investigate the complex questions in the field of aneuploidy.

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