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Chronic low-dose radiation inhibits cisplatin-induced formation of tumorous clones in Drosophila melanogaster wts/ + heterozygotes

Authors

  • Ki Moon Seong,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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    • Theses authors contributed equally to this work.
  • Cha Soon Kim,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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    • Theses authors contributed equally to this work.
  • Sun Won Seo,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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  • Byung-Sub Lee,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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  • Seon Young Nam,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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  • Kwang Hee Yang,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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  • Ji Young Kim,

    1. Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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  • Kyung-Jin Min,

    1. Department of Biological Sciences, Inha University, Incheon, Korea
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  • Young-Woo Jin

    Corresponding author
    1. Department of Planning & Research for Radiological Emergency, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Republic of Korea
    • Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea
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Correspondence

Young-Woo Jin, 388-1 Ssangmun3-Dong, Dobong-Gu, Seoul, Korea 132-703. Email: ywjin@hanmail.net

Abstract

Ionizing radiation is one of the most extensively studied carcinogens. In contrast to the detrimental effects of high-dose radiation in carcinogenesis, the biological effects of low-dose radiation remains poorly understood. In this study, we introduced adult wts/ + heterozygotes of Drosophila melanogaster as transgenic model organisms to determine the tumorigenic activity of low-dose radiation. The warts (wts) gene is a tumor suppressor gene in mice and humans that is directly involved in cell cycle regulation. Fruit flies at the first larval stage were subjected to ionizing radiation, and then tumorigenic activity was evaluated as the frequency of observed warts tumorous mosaic clones in adult flies. Low-dose irradiation alone did not cause tumorigenesis in our system. In combined treatment with a chemical carcinogen, chronic irradiation at 0.2 Gy decreased the frequency of tumorous clones induced by cisplatin. These results suggest that low-dose radiation alone is not deleterious but beneficial in tumorigenesis induced by a chemical carcinogen.

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