Conflict of interest: None.
A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice
Article first published online: 25 APR 2013
© 2013 The Authors. Journal of Digestive Diseases © 2013 Wiley Publishing Asia Pty Ltd and Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Journal of Digestive Diseases
Volume 14, Issue 6, pages 299–304, June 2013
How to Cite
Deng, K., Zhou, L. Y., Lin, S. R., Li, Y., Chen, M., Geng, Q. M. and Li, Y. W. (2013), A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice. Journal of Digestive Diseases, 14: 299–304. doi: 10.1111/1751-2980.12040
- Issue published online: 25 APR 2013
- Article first published online: 25 APR 2013
- Accepted manuscript online: 28 JAN 2013 07:01AM EST
- National Natural Science Foundation of China. Grant Number: 30973415
- early detection of cancer;
- gastric juice;
- stomach neoplasms
This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening.
Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were divided into three groups: the normal mucosa or chronic non-atrophic gastritis (NM-CNAG) group (n = 35), advanced gastric cancer (AGC) group (n = 33) and EGC group (n = 33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (P1FI) was measured.
The mean fluorescence intensity of P1FI of gastric juice in AGC (92.1 ± 10.7) and EGC (90.8 ± 12.0) groups was significantly higher than that in the NM-CNAG group (55.7 ± 7.5) (AGC vs NM-CNAG, P = 0.006 and EGC vs NM-CNAG, P = 0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [CI] 0.553–0.810, P = 0.010) and 0.655 (95% CI 0.522–0.787, P = 0.028). With the P1FI of ≥47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively.
The enhancement of P1FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.