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Expert recommendations on the application of interferon for chronic hepatitis B

Authors

  • Mo Bin Wan,

    Corresponding author
    1. Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China
    • Correspondence to: Mo Bin WAN, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China. Email: mobinwan@aliyun.com

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  • Xin Hua Weng

    1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
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  • Conflict of interest: None.
  • The study has been published in Chinese in Chin J Infect Dis 2010; 28: 193–200 (‘Expert recommendations on the treatment of chronic hepatitis B with interferon [revision 2010]’) and Chin J Infect Dis 2012; 30: 705–10 (‘Some additions to the expert recommendations on the treatment of chronic hepatitis B with interferon’), with modifications.

Abstract

To help the clinicians correctly and scientifically apply interferon for the treatment of chronic hepatitis B, more than 40 experts majored in infectious and liver diseases updated the ‘Expert recommendations on the treatment of chronic hepatitis B with interferon (2007)’ following a systematic literature review, summary of clinical experiences and thorough consultation and discussion. The updated expert recommendations primarily included fundamental new knowledge of the use of interferon and individualized interferon therapy. Specifically, we provided recommendations for implementing optimized therapeutic regimens based on quantitative changes in hepatitis B surface antigen and hepatitis B virus DNA levels 24 weeks after interferon therapy. The updated expert recommendations provided itemized details and supplement for the Guidelines for the Prevention and Treatment of Chronic Hepatitis B and they also offer a basis for individualized therapy of chronic hepatitis B with interferon.

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