Both authors contributed equally to this work.
Bio-based production of organic acids with Corynebacterium glutamicum
Article first published online: 2 DEC 2012
© 2012 The Authors. Microbial Biotechnology published by Blackwell Publishing Ltd and Society for Applied Microbiology
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: The Corynebacterium Cell Factory
Volume 6, Issue 2, pages 87–102, March 2013
How to Cite
Wieschalka, S., Blombach, B., Bott, M. and Eikmanns, B. J. (2013), Bio-based production of organic acids with Corynebacterium glutamicum. Microbial Biotechnology, 6: 87–102. doi: 10.1111/1751-7915.12013
Funding Information Work in the laboratories of the authors was supported by the Fachagentur Nachwachsende Rohstoffe (FNR) of the Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV; FNR Grants 220-095-08A and 220-095-08D; BioProChemBB project, ERA-IB programme), by the Deutsche Bundesstiftung Umwelt (DBU Grant AZ13040/05) and the Evonik Degussa AG.
- Issue published online: 15 FEB 2013
- Article first published online: 2 DEC 2012
- Manuscript Revised: 28 OCT 2012
- Manuscript Accepted: 28 OCT 2012
- Manuscript Received: 14 SEP 2012
- Fachagentur Nachwachsende Rohstoffe (FNR) of the Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz. Grant Numbers: 220-095-08A, 220-095-08D
- Deutsche Bundesstiftung Umwelt. Grant Number: AZ13040/05
- Evonik Degussa AG
The shortage of oil resources, the steadily rising oil prices and the impact of its use on the environment evokes an increasing political, industrial and technical interest for development of safe and efficient processes for the production of chemicals from renewable biomass. Thus, microbial fermentation of renewable feedstocks found its way in white biotechnology, complementing more and more traditional crude oil-based chemical processes. Rational strain design of appropriate microorganisms has become possible due to steadily increasing knowledge on metabolism and pathway regulation of industrially relevant organisms and, aside from process engineering and optimization, has an outstanding impact on improving the performance of such hosts. Corynebacterium glutamicum is well known as workhorse for the industrial production of numerous amino acids. However, recent studies also explored the usefulness of this organism for the production of several organic acids and great efforts have been made for improvement of the performance. This review summarizes the current knowledge and recent achievements on metabolic engineering approaches to tailor C. glutamicum for the bio-based production of organic acids. We focus here on the fermentative production of pyruvate, l- and d-lactate, 2-ketoisovalerate, 2-ketoglutarate, and succinate. These organic acids represent a class of compounds with manifold application ranges, e.g. in pharmaceutical and cosmetics industry, as food additives, and economically very interesting, as precursors for a variety of bulk chemicals and commercially important polymers.