Funding Information Some ideas in this review have evolved from British Biotechnology and Science Research Council-funded Grant BB/F005903/1.
Exploiting pathogens' tricks of the trade for engineering of plant disease resistance: challenges and opportunities
Article first published online: 2 JAN 2013
© 2013 The Authors. Microbial Biotechnology published by Blackwell Publishing Ltd and Society for Applied Microbiology
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: Plant-Microbe Interactions
Volume 6, Issue 3, pages 212–222, May 2013
How to Cite
Grant, M. R., Kazan, K. and Manners, J. M. (2013), Exploiting pathogens' tricks of the trade for engineering of plant disease resistance: challenges and opportunities. Microbial Biotechnology, 6: 212–222. doi: 10.1111/1751-7915.12017
- Issue published online: 15 APR 2013
- Article first published online: 2 JAN 2013
- Manuscript Accepted: 17 NOV 2012
- Manuscript Received: 28 OCT 2012
- British Biotechnology and Science Research Council. Grant Number: BB/F005903/1
With expansion of our understanding of pathogen effector strategies and the multiplicity of their host targets, it is becoming evident that novel approaches to engineering broad-spectrum resistance need to be deployed. The increasing availability of high temporal gene expression data of a range of plant–microbe interactions enables the judicious choices of promoters to fine-tune timing and magnitude of expression under specified stress conditions. We can therefore contemplate engineering a range of transgenic lines designed to interfere with pathogen virulence strategies that target plant hormone signalling or deploy specific disease resistance genes. An advantage of such an approach is that hormonal signalling is generic so if this strategy is effective, it can be easily implemented in a range of crop species. Additionally, multiple re-wired lines can be crossed to develop more effective responses to pathogens.