Funding Information Work on T3SEs in the Desveaux and Guttman labs is supported by individual grants to D.S.G and D.D. from NSERC and the Canada Research Chair program.
Phytopathogen type III effectors as probes of biological systems
Article first published online: 25 FEB 2013
© 2013 The Authors. Microbial Biotechnology published by Blackwell Publishing Ltd and Society for Applied Microbiology
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: Plant-Microbe Interactions
Volume 6, Issue 3, pages 230–240, May 2013
How to Cite
Lee, A. H.-Y., Middleton, M. A., Guttman, D. S. and Desveaux, D. (2013), Phytopathogen type III effectors as probes of biological systems. Microbial Biotechnology, 6: 230–240. doi: 10.1111/1751-7915.12042
- Issue published online: 15 APR 2013
- Article first published online: 25 FEB 2013
- Manuscript Accepted: 16 JAN 2013
- Manuscript Revised: 12 JAN 2013
- Manuscript Received: 15 OCT 2012
- Canada Research Chair program
Bacterial phytopathogens utilize a myriad of virulence factors to modulate their plant hosts in order to promote successful pathogenesis. One potent virulence strategy is to inject these virulence proteins into plant cells via the type III secretion system. Characterizing the host targets and the molecular mechanisms of type III secreted proteins, known as effectors, has illuminated our understanding of eukaryotic cell biology. As a result, these effectors can serve as molecular probes to aid in our understanding of plant cellular processes, such as immune signalling, vesicle trafficking, cytoskeleton stability and transcriptional regulation. Furthermore, given that effectors directly and specifically interact with their targets within plant cells, these virulence proteins have enormous biotechnological potential for manipulating eukaryotic systems.