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Microbiota and healthy ageing: observational and nutritional intervention studies
Article first published online: 26 MAR 2013
© 2013 The Author. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Thematic Issue: Ecological Engineering of the Intestinal Microbiome Connecting the Environment and Food to Therapy and Health
Volume 6, Issue 4, pages 326–334, July 2013
How to Cite
Brüssow, H. (2013), Microbiota and healthy ageing: observational and nutritional intervention studies. Microbial Biotechnology, 6: 326–334. doi: 10.1111/1751-7915.12048
- Issue published online: 11 JUN 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 14 FEB 2013
- Manuscript Received: 12 FEB 2013
Hundred years ago Metchnikoff associated human health and particularly healthy ageing with a specific type of gut microbiota. Classical culture methods associated a decrease in bifidobacteria and an increase in enterobacteria with ageing. Modern molecular methods blurred this simple picture and documented a substantial inter-individual variability for the gut microbiome even when stratifying the elderly subjects according to health status. Nutritional interventions with resistant starch showed consistent gut microbiota changes across studies from different geographical areas and prebiotic supplementation induced a 10-fold increase in gut bifidobacteria. However, in the ELDERMET study, microbiota changes do not precede, but follow the changes in health status of elderly subjects possibly as a consequence of diet changes.