Jung Eun Yang, So Young Choi and Jae Ho Shin equally contributed to this work.
Microbial production of lactate-containing polyesters
Article first published online: 29 MAY 2013
© 2013 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Thematic Issue on Biomaterials
Volume 6, Issue 6, pages 621–636, November 2013
How to Cite
Yang, J. E., Choi, S. Y., Shin, J. H., Park, S. J. and Lee, S. Y. (2013), Microbial production of lactate-containing polyesters. Microbial Biotechnology, 6: 621–636. doi: 10.1111/1751-7915.12066
Funding Information This work was supported by the Technology Development Program to Solve Climate Changes (Systems Metabolic Engineering for Biorefineries) from the Ministry of Education, Science, and Technology (MEST) through the National Research Foundation (NRF) of Korea (NRF-2012-C1AAA001-2012M1A2A2026556).
- Issue published online: 11 OCT 2013
- Article first published online: 29 MAY 2013
- Manuscript Accepted: 22 APR 2013
- Manuscript Revised: 19 APR 2013
- Manuscript Received: 11 MAR 2013
- Ministry of Education, Science, and Technology (MEST). Grant Number: NRF-2012-C1AAA001-2012M1A2A2026556
Due to our increasing concerns on environmental problems and limited fossil resources, biobased production of chemicals and materials through biorefinery has been attracting much attention. Optimization of the metabolic performance of microorganisms, the key biocatalysts for the efficient production of the desired target bioproducts, has been achieved by metabolic engineering. Metabolic engineering allowed more efficient production of polyhydroxyalkanoates, a family of microbial polyesters. More recently, non-natural polyesters containing lactate as a monomer have also been produced by one-step fermentation of engineered bacteria. Systems metabolic engineering integrating traditional metabolic engineering with systems biology, synthetic biology, protein/enzyme engineering through directed evolution and structural design, and evolutionary engineering, enabled microorganisms to efficiently produce natural and non-natural products. Here, we review the strategies for the metabolic engineering of microorganisms for the in vivo biosynthesis of lactate-containing polyesters and for the optimization of whole cell metabolism to efficiently produce lactate-containing polyesters. Also, major problems to be solved to further enhance the production of lactate-containing polyesters are discussed.