Funding Information This work was funded by the Swiss National Science Foundation grant no. 31003A-135808.
Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system
Article first published online: 7 OCT 2013
© 2013 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Thematic Issue: Fish Vaccines. Guest Editors: Joachim Frey, Bjarnheidur Gudmundsdottir, Beatriz Novoa and Antonio Figueras
Volume 7, Issue 5, pages 381–400, September 2014
How to Cite
Vanden Bergh, P. and Frey, J. (2014), Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system. Microbial Biotechnology, 7: 381–400. doi: 10.1111/1751-7915.12091
- Issue published online: 7 AUG 2014
- Article first published online: 7 OCT 2013
- Manuscript Accepted: 28 AUG 2013
- Manuscript Revised: 27 AUG 2013
- Manuscript Received: 29 JUL 2013
- Swiss National Science Foundation. Grant Number: 31003A-135808
Aeromonas salmonicida subsp. salmonicida is an important pathogen in salmonid aquaculture and is responsible for the typical furunculosis. The type-three secretion system (T3SS) is a major virulence system. In this work, we review structure and function of this highly sophisticated nanosyringe in A. salmonicida. Based on the literature as well as personal experimental observations, we document the genetic (re)organization, expression regulation, anatomy, putative functional origin and roles in the infectious process of this T3SS. We propose a model of pathogenesis where A. salmonicida induces a temporary immunosuppression state in fish in order to acquire free access to host tissues. Finally, we highlight putative important therapeutic and vaccine strategies to prevent furunculosis of salmonid fish.