Comparative genome analysis of Lactobacillus casei strains isolated from Actimel and Yakult products reveals marked similarities and points to a common origin
François P. Douillard, Ravi Kant, Jarmo Ritari, Lars Paulin, Airi Palva and Willem M. de Vos
In the draft genome sequence of Lactobacillus casei strain LcY originally published by Douillard and colleagues (2013), it was reported that this strain contained a ∼ 40 kb prophage region. This is incorrect and strain LcY is devoid of this prophage as based on re-analysis of both SOLiD and 454 sequencing data as well as polymerase chain reaction analysis. The genomes of L. casei strains LcA and LcY are highly similar to each other and also to some other L. casei isolates. Hence, the conclusions of our manuscript are unchanged except for the absence of a prophage in LcY. Their comparable predicted exoproteome also suggests that L. casei LcA and LcY may possess similar probiotic properties, legitimating the comparison of the in vivo studies performed with the L. casei strains used in Actimel and Yakult products. The LcY Whole Genome Shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession ARNV00000000. The revised version described relative to this paper is version ARNV02000000.