SEARCH

SEARCH BY CITATION

References

  • Aidoo, K.A., Wong, A., Alexander, D.C., Rittammer, R.A., and Jensen, S.E. (1994) Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene 147: 4146.
  • Alexander, D.C., and Jensen, S.E. (1998) Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein. J Bacteriol 180: 40684079.
  • Álvarez-Álvarez, R., Martínez-Burgo, Y., Pérez-Redondo, R., Braña, A.F., Martín, J.F., and Liras, P. (2013) Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping. Appl Microbiol Biotechnol 97: 94519463.
  • Antón, N., Mendes, M.V., Martín, J.F., and Aparicio, J.F. (2004) Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis. J Bacteriol 186: 25672575.
  • Baños, S., Pérez-Redondo, R., Koekman, B., and Liras, P. (2009) Glycerol utilization gene cluster in Streptomyces clavuligerus. Appl Environ Microbiol 75: 29912995.
  • Bate, N., Stratigopoulos, G., and Cundliffe, E. (2002) Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. Mol Microbiol 43: 449458.
  • Buttner, M.J., Chater, K.F., and Bibb, M.J. (1990) Cloning, disruption and transcriptional analysis of three RNA polymerase sigma factor genes of Streptomyces coelicolorA3(2). J Bacteriol 172: 33673378.
  • Chen, L., Chen, J., Jiang, Y., Zhang, W., Jiang, W., and Lu, Y. (2009) Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis. FEMS Microbiol Lett 298: 199207.
  • Doran, J.L., Leskiw, B.K., Aippersbach, S., and Jensen, S.E. (1990) Isolation and characterization of a β-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene. J Bacteriol 172: 49094918.
  • Fuente, A., de la Lorenzana, L.M., Martín, J.F., and Liras, P. (2002) Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways. J Bacteriol 184: 65596565.
  • Garg, R.P., and Parry, R.J. (2010) Regulation of valanimycin biosynthesis in Streptomyces viridifaciens: characterization of VlmI as a Streptomyces antibiotic regulatory protein (SARP). Microbiology 156: 472483.
  • He, X., Li, R., Pan, Y., Liu, G., and Tan, H. (2010) SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN-sanO intergenic region in Streptomyces ansochromogenes. Microbiology 156: 828837.
  • Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces Genetics. Norwich, UK: John Innes Foundation.
  • Li, R., and Townsend, C.A. (2006) Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabol Eng 8: 240252.
  • Livak, K.J., and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2–ΔΔCT. Methods 25: 402408.
  • López-García, M.T., Santamarta, I., and Liras, P. (2010) Morphological differentiation and clavulanic acid formation are affected in an S. clavuligerus ΔadpA-deleted mutant. Microbiology 156: 23542365.
  • Martín, J.F., and Liras, P. (2010) Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr Opin Microbiol 13: 263273.
  • Medema, M.H., Alam, M.T., Heijne, W.H.M., van der Berg, M.A., Müller, U., Trefzer, A., et al. (2010) Genome wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus. Microbial Biotechnol 4: 300305.
  • Mehra, S., Lian, W., Jayapal, K.P., Charaniya, S.P., Sherman, D.H., and Hu, W.-S. (2006) A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. J Ind Microbiol Biotechnol 33: 159172.
  • Pérez-Llarena, F.J., Liras, P., Rodríguez-García, A., and Martín, J.F. (1997) A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. J Bacteriol 170: 20532059.
  • Pérez-Redondo, R., Rodríguez-García, A., Martín, J.F., and Liras, P. (1998) The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene 211: 311321.
  • Pérez-Redondo, R., Rodríguez-García, A., Botas, A., Santamarta, I., Martín, J.F., and Liras, P. (2012) ArgR of Streptomyces coelicolor is a versatile regulator. PLoS ONE 7: e32697.
  • Robles-Reglero, V., Santamarta, I., Álvarez-Álvarez, R., Martín, J.F., and Liras, P. (2013) Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus. J Biotechnol 163: 6976.
  • Rodríguez, M., Núñez, L.E., Braña, A.F., Méndez, C., Salas, J.A., and Blanco, G. (2008) Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya. Mol Microbiol 69: 633645.
  • Rodríguez-García, A., Barreiro, C., Santos-Beneit, F., Sola-Landa, A., and Martín, J.F. (2007) Genome-wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a ΔphoP mutant. Proteomics 7: 24102429.
  • Santamarta, I., López-García, M.T., Kurt, A., Nárdiz, N., Alvarez-Álvarez, R., Pérez-Redondo, R., et al. (2011) Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus. Mol Microbiol 81: 968981.
  • Sartor, M., Schwanekamp, J., Halbleib, D., Mohamed, I., Karyala, S., Medvedovic, M., et al. (2004) Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques 36: 790796.
  • Smyth, G.K. (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: 15446115.
  • Smyth, G.K., and Speed, T.P. (2003) Normalization of cDNA microarray data. Methods 31: 265273.
  • Smyth, G.K., Michaud, J., and Scott, H.S. (2005) Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21: 20672075.
  • Tahlan, K., Anders, C., Wong, A., Mosher, R.H., Beatty, P.H., Brumlik, M.J., et al. (2007) 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Chem Biol 14: 131142.
  • Thai, W., Paradkar, A.S., and Jensen, S.E. (2001) Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus. Microbiology 147: 325335.
  • Wietzorrek, A., and Bibb, M. (1997) A novel family of proteins that regulate antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 25: 11771184.
  • Wilson, D.J., Xue, Y., Reynolds, K.E., and Sherman, D.H. (2001) Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J Bacteriol 183: 34683475.