Funding Information This work has been supported by projects AGL2011-27884 and Consolider Ingenio 2010 FUN-C-FOOD CSD2007-00063 from Ministerio de Ciencia e Innovación, project POII10-0178-4685 from Junta de Comunidades de Castilla-La Mancha and the European Regional Development Fund (ERDF), and ALIBIRD-CM S2009/AGR-1469 from Comunidad de Madrid.
Synthesis of novel bioactive lactose-derived oligosaccharides by microbial glycoside hydrolases
Article first published online: 1 APR 2014
© 2014 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 7, Issue 4, pages 315–331, July 2014
How to Cite
Díez-Municio, M., Herrero, M., Olano, A. and Moreno, F. J. (2014), Synthesis of novel bioactive lactose-derived oligosaccharides by microbial glycoside hydrolases. Microbial Biotechnology, 7: 315–331. doi: 10.1111/1751-7915.12124
- Issue published online: 5 JUN 2014
- Article first published online: 1 APR 2014
- Manuscript Accepted: 23 FEB 2014
- Manuscript Revised: 21 FEB 2014
- Manuscript Received: 13 DEC 2013
- Ministerio de Ciencia e Innovación. Grant Numbers: AGL2011-27884, CSD2007-00063
- Junta de Comunidades de Castilla-La Mancha and the European Regional Development Fund (ERDF). Grant Number: POII10-0178-4685
- Comunidad de Madrid. Grant Number: ALIBIRD-CM S2009/AGR-1469
Prebiotic oligosaccharides are increasingly demanded within the Food Science domain because of the interesting healthy properties that these compounds may induce to the organism, thanks to their beneficial intestinal microbiota growth promotion ability. In this regard, the development of new efficient, convenient and affordable methods to obtain this class of compounds might expand even further their use as functional ingredients. This review presents an overview on the most recent interesting approaches to synthesize lactose-derived oligosaccharides with potential prebiotic activity paying special focus on the microbial glycoside hydrolases that can be effectively employed to obtain these prebiotic compounds. The most notable advantages of using lactose-derived carbohydrates such as lactosucrose, galactooligosaccharides from lactulose, lactulosucrose and 2-α-glucosyl-lactose are also described and commented.