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Vitamin D and Type 2 diabetes mellitus (维生素D与2型糖尿病)

Authors

  • Yan Xuan,

    1. Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China
    2. Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China
    3. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China
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  • Hong-yan Zhao,

    Corresponding author
    1. Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China
    2. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China
    • Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China
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  • Jian-Min Liu

    Corresponding author
    1. Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China
    2. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China
    • Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China
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Correspondence

Hong-yan Zhao and Jian-Min Liu, Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 197 Rui-jin Er Road, Shanghai 200025, China.

Tel: +86 21 6437 0045

Fax: +86 21 6437 3514

Email: Hong-yan Zhao, hyanzhao@163.com and Jian-min Liu, liujianmin@medmail.com.cn

Abstract

Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus (T2DM). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM. Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM. More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.

摘要

随着来自人体临床及动物基础实验的深入研究,维生素D缺乏已经被视作2型糖尿病的危险因素。维生素D涉及2型糖尿病的多个发病环节,如胰岛β细胞功能异常、胰岛素抵抗和全身炎症反应。维生素D可以通过自身受体或调节钙平衡,以直接或间接的方式影响2型糖尿病的发生和发展。许多观察性研究发现缺乏维生素D与2型糖尿病的发病有关。但需要有更多的随机双盲试验,了解补充维生素D是否会对胰岛素敏感性、胰岛素分泌和2型糖尿病的发生起到作用。

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